Detailed information of TA system TA144760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 150599..151134
• Replicon: plasmid pASB05p2
• Accession: NZ_CP046724
• Organism: Pantoea agglomerans strain ASB05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8X8DPA1
• Locus tag: PAASB05_RS21870
• Protein ID: WP_010257115.1
• Coordinates: 150847..151134 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: PAASB05_RS21865
• Protein ID: WP_033759975.1
• Coordinates: 150599..150850 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAASB05_RS21845	146202..146471	-	270	WP_010257103.1	DUF1471 domain-containing protein	-
PAASB05_RS21850	146747..147883	-	1137	WP_022624279.1	HlyD family secretion protein	-
PAASB05_RS21855	147885..148211	-	327	WP_033759973.1	DUF3302 domain-containing protein	-
PAASB05_RS21860	148806..150458	+	1653	WP_158132464.1	intermembrane transport protein PqiB	-
PAASB05_RS21865	150599..150850	+	252	WP_033759975.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PAASB05_RS21870	150847..151134	+	288	WP_010257115.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PAASB05_RS21875	151497..151811	+	315	WP_033759977.1	hypothetical protein	-
PAASB05_RS21880	151808..152614	-	807	WP_158132488.1	DUF4225 domain-containing protein	-
PAASB05_RS21885	152718..152894	-	177	WP_158132465.1	hypothetical protein	-
PAASB05_RS21890	153233..153517	-	285	Protein_124	general secretion pathway protein GspD	-
PAASB05_RS21895	153546..153758	+	213	WP_158132466.1	hypothetical protein	-
PAASB05_RS21900	153862..154119	+	258	WP_033774102.1	hypothetical protein	-
PAASB05_RS21905	154191..154667	+	477	WP_033774104.1	hypothetical protein	-
PAASB05_RS21910	154688..154987	+	300	Protein_128	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..207454	207454

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11173.08 Da
• Isoelectric Point: 10.3856

>T144760 WP_010257115.1 NZ_CP046724:150847-151134 [Pantoea agglomerans]
VSYTVKFREEAFKEWQKLDKSLQQQFAKKLKKCCDNPHIPSARLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVAVGK
RERSDVYHLASERMR

Nucleotide

• Length: 288 bp

>T144760 NZ_CP062240:c1586433-1585111 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9120.43 Da
• Isoelectric Point: 3.9507

>AT144760 WP_033759975.1 NZ_CP046724:150599-150850 [Pantoea agglomerans]
MPNIILSDTSASVSELKKNPMATVNAGDGYPVAILNRNQPAFYCVPAELYEQMLDALDDQELVKLVSERSKQPLIDVDLD
ALL

Nucleotide

• Length: 252 bp

>AT144760 NZ_CP062240:c1586699-1586433 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA