Detailed information of TA system TA144759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 115221..115747
• Replicon: plasmid pASB05p2
• Accession: NZ_CP046724
• Organism: Pantoea agglomerans strain ASB05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X2SUG9
• Locus tag: PAASB05_RS21710
• Protein ID: WP_033759930.1
• Coordinates: 115221..115508 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8X8DPB7
• Locus tag: PAASB05_RS21715
• Protein ID: WP_010257033.1
• Coordinates: 115508..115747 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAASB05_RS21690	111309..112334	-	1026	WP_010671942.1	alpha/beta hydrolase	-
PAASB05_RS21695	112403..113596	-	1194	WP_197746041.1	MFS transporter	-
PAASB05_RS21700	113730..114626	+	897	WP_010257019.1	LysR family transcriptional regulator	-
PAASB05_RS21705	114690..114866	-	177	WP_010257023.1	stress-induced protein	-
PAASB05_RS21710	115221..115508	-	288	WP_033759930.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PAASB05_RS21715	115508..115747	-	240	WP_010257033.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PAASB05_RS21720	116107..118080	+	1974	WP_158132456.1	FIST C-terminal domain-containing protein	-
PAASB05_RS21725	118185..119201	+	1017	WP_010257039.1	NAD(P)-dependent alcohol dehydrogenase	-
PAASB05_RS21730	119251..119919	-	669	WP_031292291.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..207454	207454

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11076.95 Da
• Isoelectric Point: 10.3173

>T144759 WP_033759930.1 NZ_CP046724:c115508-115221 [Pantoea agglomerans]
MTWQLEFDQRALKEWRKLGPTVREQLKKKLAECLESPRIEANKLSGMPDCYKIKLKSSGYRLVYQVIDDRVVVFVVAVGK
RERSEVYSAASRRLS

Nucleotide

• Length: 288 bp

>T144759 NZ_CP062240:1503543-1503719 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9002.33 Da
• Isoelectric Point: 4.3410

>AT144759 WP_010257033.1 NZ_CP046724:c115747-115508 [Pantoea agglomerans]
MGTINIRIDDDLKTRSYAALEKMGVTPSDALRLMLEYIADNERLPFKQTLLSDEDAALVDIVKERLRNPEPVRVTLDDL

Nucleotide

• Length: 240 bp

>AT144759 NZ_CP062240:1503765-1504181 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A7X2SUG9