Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3320808..3321439 Replicon chromosome
Accession NZ_CP046722
Organism Pantoea agglomerans strain ASB05

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PAASB05_RS15575 Protein ID WP_158131996.1
Coordinates 3321260..3321439 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8X8DTB6
Locus tag PAASB05_RS15570 Protein ID WP_010253955.1
Coordinates 3320808..3321233 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAASB05_RS15550 3317530..3318039 - 510 WP_010253965.1 phenolic acid decarboxylase -
PAASB05_RS15555 3318145..3319044 + 900 WP_158131994.1 LysR family transcriptional regulator -
PAASB05_RS15560 3319471..3320400 - 930 WP_158131995.1 Rpn family recombination-promoting nuclease/putative transposase -
PAASB05_RS15565 3320586..3320726 - 141 WP_033756575.1 CRISPR-associated protein Cas1 -
PAASB05_RS15570 3320808..3321233 - 426 WP_010253955.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PAASB05_RS15575 3321260..3321439 - 180 WP_158131996.1 type II toxin-antitoxin system HicA family toxin Toxin
PAASB05_RS15580 3321622..3323046 - 1425 WP_010253950.1 dihydrolipoyl dehydrogenase -
PAASB05_RS15585 3323207..3325108 - 1902 WP_010671838.1 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6615.73 Da        Isoelectric Point: 10.8278

>T144755 WP_158131996.1 NZ_CP046722:c3321439-3321260 [Pantoea agglomerans]
MDSSTLISEMKADGWVLTRIYGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI

Download         Length: 180 bp

>T144755 NZ_CP062240:c1264731-1264624 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15422.60 Da        Isoelectric Point: 4.7662

>AT144755 WP_010253955.1 NZ_CP046722:c3321233-3320808 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK

Download         Length: 426 bp

>AT144755 NZ_CP062240:1264779-1264845 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References