Detailed information of TA system TA144752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2074468..2076029
• Replicon: chromosome
• Accession: NZ_CP046722
• Organism: Pantoea agglomerans strain ASB05

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8I0LDJ4
• Locus tag: PAASB05_RS09570
• Protein ID: WP_010244882.1
• Coordinates: 2074716..2076029 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PAASB05_RS09565
• Protein ID: WP_010670157.1
• Coordinates: 2074468..2074716 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAASB05_RS09545	2069715..2071940	+	2226	WP_158131692.1	iron ABC transporter permease	-
PAASB05_RS09550	2071937..2072998	+	1062	WP_033757668.1	ABC transporter ATP-binding protein	-
PAASB05_RS09555	2073022..2073816	+	795	WP_158131693.1	inositol monophosphatase	-
PAASB05_RS09560	2073850..2074287	-	438	Protein_1858	GNAT family N-acetyltransferase	-
PAASB05_RS09565	2074468..2074716	+	249	WP_010670157.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
PAASB05_RS09570	2074716..2076029	+	1314	WP_010244882.1	type II toxin-antitoxin system HipA family toxin	Toxin
PAASB05_RS09575	2076134..2076340	+	207	WP_010244885.1	type II toxin-antitoxin system MqsA family antitoxin	-
PAASB05_RS09580	2076512..2077933	+	1422	WP_158131694.1	M24 family metallopeptidase	-
PAASB05_RS09585	2078009..2080054	+	2046	WP_157352163.1	FUSC family protein	-
PAASB05_RS09590	2080285..2080620	-	336	WP_158131695.1	gamma-glutamylcyclotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-54)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49175.74 Da
• Isoelectric Point: 8.4299

>T144752 WP_010244882.1 NZ_CP046722:2074716-2076029 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVRAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Nucleotide

• Length: 1314 bp

>T144752 NZ_CP062240:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9319.56 Da
• Isoelectric Point: 5.0775

>AT144752 WP_010670157.1 NZ_CP046722:2074468-2074716 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEAGAPQVHDED
EW

Nucleotide

• Length: 249 bp

>AT144752 NZ_CP062240:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA