Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 7038..7630 Replicon plasmid pT16R-3
Accession NZ_CP046719
Organism Escherichia coli strain T16R

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag GPL39_RS24360 Protein ID WP_000520549.1
Coordinates 7382..7630 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag GPL39_RS24355 Protein ID WP_000681613.1
Coordinates 7038..7385 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPL39_RS24325 3043..3315 - 273 WP_001328551.1 TrbC/VirB2 family protein -
GPL39_RS24330 3383..4003 - 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
GPL39_RS24335 4359..4574 - 216 WP_000760375.1 EexN family lipoprotein -
GPL39_RS24340 4571..4864 - 294 WP_060598542.1 LuxR family transcriptional regulator -
GPL39_RS24345 4941..6170 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
GPL39_RS24350 6174..6677 - 504 WP_000781813.1 hypothetical protein -
GPL39_RS24355 7038..7385 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GPL39_RS24360 7382..7630 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
GPL39_RS24365 7935..8285 - 351 WP_000854259.1 hypothetical protein -
GPL39_RS24370 8376..8675 - 300 WP_000650309.1 hypothetical protein -
GPL39_RS24375 9129..9356 - 228 WP_000801440.1 hypothetical protein -
GPL39_RS24380 9343..9594 - 252 WP_001230707.1 hypothetical protein -
GPL39_RS24385 9591..10133 - 543 WP_001083906.1 hypothetical protein -
GPL39_RS24390 10238..10753 - 516 WP_001025395.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..33309 33309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T144746 WP_000520549.1 NZ_CP046719:c7630-7382 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

>T144746 NZ_CP062239:c3693447-3693340 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT144746 WP_000681613.1 NZ_CP046719:c7385-7038 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp

>AT144746 NZ_CP062239:3693496-3693562 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References