Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 6632538..6633114 Replicon chromosome
Accession NZ_CP046703
Organism Nostoc sp. ATCC 53789

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GJB62_RS27480 Protein ID WP_114082330.1
Coordinates 6632538..6632897 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GJB62_RS27485 Protein ID WP_114082329.1
Coordinates 6632884..6633114 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJB62_RS27465 6628325..6629524 + 1200 WP_114082333.1 DUF4159 domain-containing protein -
GJB62_RS27470 6629831..6630853 - 1023 WP_114082332.1 radical SAM protein -
GJB62_RS27475 6630900..6632216 - 1317 WP_114082331.1 three-Cys-motif partner protein TcmP -
GJB62_RS27480 6632538..6632897 - 360 WP_114082330.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GJB62_RS27485 6632884..6633114 - 231 WP_114082329.1 CopG family transcriptional regulator Antitoxin
GJB62_RS27490 6633305..6634099 - 795 WP_114082328.1 Tab2/Atab2 family RNA-binding protein -
GJB62_RS27495 6634176..6634445 - 270 WP_114082327.1 YciI family protein -
GJB62_RS27500 6634558..6637008 - 2451 WP_114082326.1 phenylalanine--tRNA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13243.35 Da        Isoelectric Point: 7.1630

>T144720 WP_114082330.1 NZ_CP046703:c6632897-6632538 [Nostoc sp. ATCC 53789]
MPGSNLTYQRGEIRWVNLDPTVGAEAKKIRACLIVQNDIMNQYGLLTIVIPFRPGSKQAPYVVNVKATPNNGLDQDRFID
IGQIRAVDHSRILGLVGVLESEYWELIHTALNVVLGFVV

Download         Length: 360 bp

>T144720 NZ_CP062231:3587780-3588064 [Rhizobium sp. TH2]
ATGATCCAAAGCTATCGGGACAAACGCACGGAGACATTTGCGAACGGTGCGTTCGTCCGGGAGTTCCAAGGGTTTGCCAA
GCAGGCATACAAGCGTCTCGACATTCTTGACGCCGCGACGCGGCTTGATGAACTGAGGCAATTGCCGAGCAACCAGCTGG
AAGCGCTAAGGGGCAACAGAAGCGGCCAATTTAGCATCAGGATCAATGAACAATACCGTATATGCTTTGTCTGGCGAAAT
GACATGCCAGGTCCGGAAGAAGTTGAGATCGTCGATTACCACTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8565.59 Da        Isoelectric Point: 4.0470

>AT144720 WP_114082329.1 NZ_CP046703:c6633114-6632884 [Nostoc sp. ATCC 53789]
MLKVTITLEEDILQFVDQYAQGNRSAYINTLLAEHRRQILAAEMIAALKQDAEDPEYQAEIATWDSVVGDGINARE

Download         Length: 231 bp

>AT144720 NZ_CP062231:3588074-3588361 [Rhizobium sp. TH2]
ATGAACCAGCGCCCCGCTATCCACCCTGGTGAAATACTGAGCGACGAGTTGTCGGAAATTGGCGTCGCTGCCGCCGAACT
CGCGCGCCAGATCGACGTGCCTCCGAACCGCATCAGTCAGATCATCAACGGCAAGAGAAGTATCACGGGAGACACCGCCC
TACGGCTGGGACATTGGTTCGGCACGACGGCGCAGTTCTGGCTCAACCTGCAAACCAATTATGAACTGCGGCTTGCGGCG
GAACGCTCCGGCGATGCAATCGCCCGGCTGCCCAGGAGGGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References