Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 2025228..2026814 | Replicon | chromosome |
| Accession | NZ_CP046674 | ||
| Organism | Ralstonia nicotianae strain RS | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | GO999_RS09135 | Protein ID | WP_211906157.1 |
| Coordinates | 2025477..2026814 (+) | Length | 446 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A223GLT8 |
| Locus tag | GO999_RS09130 | Protein ID | WP_028853251.1 |
| Coordinates | 2025228..2025473 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GO999_RS09105 (GO999_09090) | 2021291..2022217 | - | 927 | WP_011001401.1 | muramoyltetrapeptide carboxypeptidase | - |
| GO999_RS09110 (GO999_09095) | 2022214..2022765 | - | 552 | WP_016727233.1 | tRNA adenosine(34) deaminase TadA | - |
| GO999_RS09115 (GO999_09100) | 2022785..2023261 | - | 477 | WP_011001399.1 | 6-carboxytetrahydropterin synthase QueD | - |
| GO999_RS09120 (GO999_09105) | 2023329..2023967 | - | 639 | WP_020831956.1 | 7-carboxy-7-deazaguanine synthase | - |
| GO999_RS24685 | 2024139..2024258 | + | 120 | Protein_1809 | 2-hydroxychromene-2-carboxylate isomerase | - |
| GO999_RS09125 (GO999_09110) | 2024285..2025124 | + | 840 | WP_016725278.1 | oxaloacetate decarboxylase | - |
| GO999_RS09130 (GO999_09115) | 2025228..2025473 | + | 246 | WP_028853251.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| GO999_RS09135 (GO999_09120) | 2025477..2026814 | + | 1338 | WP_211906157.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| GO999_RS09140 (GO999_09125) | 2026811..2028013 | + | 1203 | WP_071507715.1 | MFS transporter | - |
| GO999_RS09145 (GO999_09130) | 2028239..2028967 | + | 729 | WP_197361969.1 | DsbA family protein | - |
| GO999_RS09150 (GO999_09135) | 2028980..2029576 | - | 597 | WP_249215014.1 | RNA 2',3'-cyclic phosphodiesterase | - |
| GO999_RS09155 (GO999_09140) | 2029724..2030422 | - | 699 | WP_019718855.1 | protocatechuate 3,4-dioxygenase subunit alpha | - |
| GO999_RS09160 (GO999_09145) | 2030419..2031159 | - | 741 | WP_011001390.1 | protocatechuate 3,4-dioxygenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 446 a.a. Molecular weight: 48826.84 Da Isoelectric Point: 6.5760
>T144714 WP_211906157.1 NZ_CP046674:2025477-2026814 [Ralstonia nicotianae]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFADMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDAWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGTSKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFADMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP
Download Length: 1338 bp
>T144714 NZ_CP062231:638926-639207 [Rhizobium sp. TH2]
ATGCGGACGATTAAATTCTCCAATAAATTCAAGCGCGATTACAAGCGAGAGAAAAGTGGCCGATCAGCCAAGAACCTCGA
TCCGCTTTTGAATGAGATTGTGCAGATTCTTGTCGCCGATGAGCAGTTGCCGAGGAAGAATTTCGATCATCCGCTCACTG
GTAATTGGATTGACTGTCGAGATTGTCATGTGAGGCCGGACCTAGTGCTTATTTATCGCAAACTGGGCGATGATGTGCTG
GAATTAGTGCGGCTTGGTTCGCATAGCGAATTGGGGCTTTGA
ATGCGGACGATTAAATTCTCCAATAAATTCAAGCGCGATTACAAGCGAGAGAAAAGTGGCCGATCAGCCAAGAACCTCGA
TCCGCTTTTGAATGAGATTGTGCAGATTCTTGTCGCCGATGAGCAGTTGCCGAGGAAGAATTTCGATCATCCGCTCACTG
GTAATTGGATTGACTGTCGAGATTGTCATGTGAGGCCGGACCTAGTGCTTATTTATCGCAAACTGGGCGATGATGTGCTG
GAATTAGTGCGGCTTGGTTCGCATAGCGAATTGGGGCTTTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8482.80 Da Isoelectric Point: 10.4693
>AT144714 WP_028853251.1 NZ_CP046674:2025228-2025473 [Ralstonia nicotianae]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAAAAPAD
W
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAAAAPAD
W
Download Length: 246 bp
>AT144714 NZ_CP062231:638676-638939 [Rhizobium sp. TH2]
ATGAGCGAGAATGCTGTTGTTCGAGCCCGAATTAACGAGGACGTGAAGAACGAAGCGTCAGCTGTTCTGGACGCGATGGG
ACTTACTGTTTCCGACGCATTCCGGATGATGATGGTACGGATCGCACGCGAGAAGGCGCTCCCCTTTGACCCACTCATTC
CGAACGATGAGACGATCGAAGCCATCAAGGCGGCGCGACGCGGCGAACTGACGACCGTTGGTTCGGTTGACGAGCTTTTT
GCGAGCCTCAATGCGGACGATTAA
ATGAGCGAGAATGCTGTTGTTCGAGCCCGAATTAACGAGGACGTGAAGAACGAAGCGTCAGCTGTTCTGGACGCGATGGG
ACTTACTGTTTCCGACGCATTCCGGATGATGATGGTACGGATCGCACGCGAGAAGGCGCTCCCCTTTGACCCACTCATTC
CGAACGATGAGACGATCGAAGCCATCAAGGCGGCGCGACGCGGCGAACTGACGACCGTTGGTTCGGTTGACGAGCTTTTT
GCGAGCCTCAATGCGGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|