Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4396915..4397594 Replicon chromosome
Accession NZ_CP046673
Organism Citrobacter sp. 172116965

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag GPJ68_RS21370 Protein ID WP_014641112.1
Coordinates 4396915..4397256 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag GPJ68_RS21375 Protein ID WP_001004647.1
Coordinates 4397277..4397594 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ68_RS21350 4392246..4393991 + 1746 WP_019077713.1 DNA primase -
GPJ68_RS21355 4394156..4396000 + 1845 WP_016154549.1 RNA polymerase sigma factor RpoD -
GPJ68_RS21360 4396046..4396552 - 507 WP_080859510.1 G/U mismatch-specific DNA glycosylase -
GPJ68_RS21370 4396915..4397256 - 342 WP_014641112.1 TA system toxin CbtA family protein Toxin
GPJ68_RS21375 4397277..4397594 - 318 WP_001004647.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GPJ68_RS21380 4397623..4398105 - 483 WP_180837426.1 DNA repair protein RadC -
GPJ68_RS21385 4398114..4398572 - 459 WP_000211839.1 antirestriction protein -
GPJ68_RS21390 4398674..4398913 - 240 WP_001115184.1 DUF905 domain-containing protein -
GPJ68_RS21395 4399004..4402468 - 3465 WP_000828064.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13031.28 Da        Isoelectric Point: 10.5786

>T144712 WP_014641112.1 NZ_CP046673:c4397256-4396915 [Citrobacter sp. 172116965]
MKTLPATTLRVVKPCLSPVAVWKMLLTRLLEQHYGLTLNDTPFSKERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRKNLVR

Download         Length: 342 bp

>T144712 NZ_CP062229:c5979848-5979342 [Mesorhizobium onobrychidis]
ATGCCTGAAAGCAGACTGAGCCTATGGCGTGCCTTCGTGCCGCGTTGGGCGCATCTGCCGCTTTCCGGCGAAGGAGCGGC
CCGCTTTGGCGGTCGCTGGAATCCGGTGGGCACCCCGGCGATCTATGCCGCGCGGGAATTGTCCACTGCTTGGGCGGAGT
ACAATCAGGGCTTTGTCCAGCATCCGGCGCTGATTGCGCAGCTCGAACTTTCAGGCGCGCGGCTGGCCGACCTGACGGAC
GCTGACGTGCTGACCAAGTTCGGCGTCACGGCAGACATTCACCGATGTGAATGGCGCGACATCATGGATCAAGGCCTGGT
GCCTGACACGCACACGCTGAGAGATCGCCTGATTGCCGATAGGCAGCACGGTGTGATCTACCCGTCCTTCATGTCGCCGG
GCGGCACTTGCGTCGCCCTCTGGCGATGGAACGAGAGCAACGCACCCCGTCTGAAGATCATCGATCCCGACCATCGCTTG
CCGAAAACGCCGGCTTCATGGCTTTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12111.73 Da        Isoelectric Point: 6.6252

>AT144712 WP_001004647.1 NZ_CP046673:c4397594-4397277 [Citrobacter sp. 172116965]
VNEMTWGLQRDVTPRFGVRLVQESNRLHYLSDRASITGKFSDVECLRLDEAFPHFVRQMELMLTTGDLNPRHTHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT144712 NZ_CP062229:c5980212-5979841 [Mesorhizobium onobrychidis]
ATGAATACCGCAGCCCTCGACATTCGAGCATCGCGCTTTGGCGAGGAACGGACGCCATTTCTTTCGGCAAGACGGGTGGC
TGAACTGCTGGGCGTCAATCTGACCGAACTGGCGGGCCTGATCGGCGTCGCGCGCAACACGCTTGCCGCCAAGACCGGCG
CGCGCAAGGTCGACGCCGCATTGAGCCCGATTGTCCGTATCCTGGCGATGGCAGGCGAGATGGCCGGCGATGAACAGCGT
GCGGCGATCTGGTTCAAGCATCAGCCAATCCCCGGCTGGGCGGGAAAGACCGCCTACGATCTCGTTCGAGAGGGCAAAAC
GGACAAGGTGCTTGCCTATCTGGAGGCAGTCCGCTCCGGCATCTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References