Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4305740..4306543 Replicon chromosome
Accession NZ_CP046673
Organism Citrobacter sp. 172116965

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7L6TYH6
Locus tag GPJ68_RS20925 Protein ID WP_047358707.1
Coordinates 4306163..4306543 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7L6TXP6
Locus tag GPJ68_RS20920 Protein ID WP_047358708.1
Coordinates 4305740..4306105 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ68_RS20880 4300813..4301700 + 888 WP_047358715.1 50S ribosome-binding GTPase -
GPJ68_RS20885 4301906..4302307 + 402 WP_047358714.1 hypothetical protein -
GPJ68_RS20890 4302404..4302871 + 468 WP_047358713.1 hypothetical protein -
GPJ68_RS20895 4303062..4303313 + 252 WP_047358712.1 DUF905 family protein -
GPJ68_RS20900 4303431..4304249 + 819 WP_047358711.1 DUF945 domain-containing protein -
GPJ68_RS20905 4304518..4304991 + 474 WP_047358733.1 antirestriction protein -
GPJ68_RS20910 4305004..4305483 + 480 WP_047358710.1 DNA repair protein RadC -
GPJ68_RS20915 4305497..4305718 + 222 WP_047358709.1 DUF987 domain-containing protein -
GPJ68_RS20920 4305740..4306105 + 366 WP_047358708.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GPJ68_RS20925 4306163..4306543 + 381 WP_047358707.1 TA system toxin CbtA family protein Toxin
GPJ68_RS20930 4306540..4307031 + 492 WP_047358706.1 hypothetical protein -
GPJ68_RS20935 4307353..4308201 + 849 WP_047358705.1 DUF4942 domain-containing protein -
GPJ68_RS20940 4308911..4309756 - 846 WP_016247599.1 hypothetical protein -
GPJ68_RS20945 4310204..4310740 - 537 WP_180836967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA 4287969..4312065 24096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14216.38 Da        Isoelectric Point: 10.0929

>T144711 WP_047358707.1 NZ_CP046673:4306163-4306543 [Citrobacter sp. 172116965]
MQTLSAIPTRKAPSHPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

>T144711 NZ_CP062229:3311684-3312160 [Mesorhizobium onobrychidis]
ATGCTGTCGGCGCCTACGCCTCTTGCCGAAAACCACGATCTGGAACTTTTCCAAAGCGGGAGCGAGAGCCTGGATCAATG
GCTTCGTCGCAGGGCGCGCGCCAACCAGATCAGCGGCGCGTCGCGTACTTATGTGGTAACGGAAGGCATGCGCGTTGTCG
GCTGCTACTGTCTCTCGTCGGGCGGGCTTGATCTTGCGGAAGCGCCAGGCGCCATTCGCCGCAACATGCCAGATCCCGTT
CCAATGGCTGTGCTCGGGCGTCTCGCCGTGGACGCTGGCTGGCAAGGGAAGGGGCTAGGCGCAGCGCTGTTGCAAGACGC
CGTTCTGCGCACTGGTCATGCCGCGACGATCCTCGGGATTCGCGGCATTTTTGTTCATGCCATATCGGCTGAAGCGAAAG
CCTTCTACGAGCACTACGGCTTTGCGGCTTCCCCGAAAAATCCGATGACCCTCGTGCTCTCGCTAAAGGCGCATTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13417.25 Da        Isoelectric Point: 6.4780

>AT144711 WP_047358708.1 NZ_CP046673:4305740-4306105 [Citrobacter sp. 172116965]
MSNQLPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAMYPTPDNSITR

Download         Length: 366 bp

>AT144711 NZ_CP062229:3311403-3311684 [Mesorhizobium onobrychidis]
ATGACAAAGACTACACCTGAGACCCACGCCAAGCCTGTCAATCTGCGCATCCGAGAGGATGTACGCATTCTGATTGACCG
CGCCGCGAAAATACGCGGGAAAACCCGCTCTGACTTTATGATCGATGCCGCCTACCGCGCGGCCGAGGACACGCTGCTCG
ACCAAGCGCTGATCAAGGTGGATCCCGAGAGTTACCGGCATTATCTCGACATCCTTGATGAACCACCGAGCGGTGAGGGT
TTTGCACGCCTTATGAACGCGCCCAAGCCCTGGCAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TYH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6TXP6

References