Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2557190..2557826 Replicon chromosome
Accession NZ_CP046673
Organism Citrobacter sp. 172116965

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag GPJ68_RS12365 Protein ID WP_049259794.1
Coordinates 2557638..2557826 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GPJ68_RS12360 Protein ID WP_131382557.1
Coordinates 2557190..2557606 (-) Length 139 a.a.

Genomic Context

GPJ68_RS12370GPJ68_RS12375GPJ68_RS12380GPJ68_RS12385GPJ68_RS12340GPJ68_RS12345GPJ68_RS12350GPJ68_RS12355GPJ68_RS12360GPJ68_RS12365
Location: 2558090..2559493 (1404 bp)
Type: Others
Protein ID: WP_016153156.1
Location: 2559493..2560503 (1011 bp)
Type: Others
Protein ID: WP_180837399.1
Location: 2560503..2560628 (126 bp)
Type: Others
Protein ID: WP_104651600.1
Location: 2560818..2561048 (231 bp)
Type: Others
Protein ID: WP_019076831.1
Location: 2552235..2553179 (945 bp)
Type: Others
Protein ID: WP_016153152.1
Location: 2553180..2554196 (1017 bp)
Type: Others
Protein ID: WP_016153153.1
Location: 2554213..2555358 (1146 bp)
Type: Others
Protein ID: WP_016153154.1
Location: 2555688..2557097 (1410 bp)
Type: Others
Protein ID: WP_019076828.1
Location: 2557190..2557606 (417 bp)
Type: Antitoxin
Protein ID: WP_131382557.1
Location: 2557638..2557826 (189 bp)
Type: Toxin
Protein ID: WP_049259794.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPJ68_RS123402552235..2553179-945WP_016153152.1ABC transporter permease-
GPJ68_RS123452553180..2554196-1017WP_016153153.1ABC transporter ATP-binding protein-
GPJ68_RS123502554213..2555358-1146WP_016153154.1ABC transporter substrate-binding protein-
GPJ68_RS123552555688..2557097-1410WP_019076828.1PLP-dependent aminotransferase family protein-
GPJ68_RS123602557190..2557606-417WP_131382557.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
GPJ68_RS123652557638..2557826-189WP_049259794.1type II toxin-antitoxin system HicA family toxinToxin
GPJ68_RS123702558090..2559493+1404WP_016153156.1cytochrome ubiquinol oxidase subunit I-
GPJ68_RS123752559493..2560503+1011WP_180837399.1cytochrome d ubiquinol oxidase subunit II-
GPJ68_RS123802560503..2560628+126WP_104651600.1DUF2474 domain-containing protein-
GPJ68_RS123852560818..2561048+231WP_019076831.1DUF2554 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T144709 WP_049259794.1 NZ_CP046673:c2557826-2557638 [Citrobacter sp. 172116965]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

>T144709 NZ_CP062228:4895344-4895721 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT144709 WP_131382557.1 NZ_CP046673:c2557606-2557190 [Citrobacter sp. 172116965]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp

>AT144709 NZ_CP062228:4894886-4895254 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2I8S6E9

Antitoxin

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Source
ID
Structure
No matching records found

References