Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1277158..1277778 Replicon chromosome
Accession NZ_CP046673
Organism Citrobacter sp. 172116965

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GPJ68_RS06070 Protein ID WP_002892050.1
Coordinates 1277158..1277376 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag GPJ68_RS06075 Protein ID WP_003021733.1
Coordinates 1277404..1277778 (-) Length 125 a.a.

Genomic Context

GPJ68_RS06035GPJ68_RS06040GPJ68_RS06050GPJ68_RS06055GPJ68_RS06045GPJ68_RS06060GPJ68_RS06065GPJ68_RS06070GPJ68_RS06075GPJ68_RS06080GPJ68_RS06085
Location: 1272517..1273146 (630 bp)
Type: Others
Protein ID: WP_016155872.1
Location: 1273211..1273564 (354 bp)
Type: Others
Protein ID: WP_003831033.1
Location: 1275358..1275618 (261 bp)
Type: Others
Protein ID: WP_104651311.1
Location: 1275620..1275760 (141 bp)
Type: Others
Protein ID: WP_005125190.1
Location: 1273616..1275169 (1554 bp)
Type: Others
Protein ID: WP_180837176.1
Location: 1275839..1276309 (471 bp)
Type: Others
Protein ID: WP_016152071.1
Location: 1276426..1276977 (552 bp)
Type: Others
Protein ID: WP_103283555.1
Location: 1277158..1277376 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Location: 1277404..1277778 (375 bp)
Type: Antitoxin
Protein ID: WP_003021733.1
Location: 1278266..1281415 (3150 bp)
Type: Others
Protein ID: WP_016152073.1
Location: 1281438..1282631 (1194 bp)
Type: Others
Protein ID: WP_047416860.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPJ68_RS060351272517..1273146+630WP_016155872.1membrane protein-
GPJ68_RS060401273211..1273564+354WP_003831033.1DUF1428 family protein-
GPJ68_RS060451273616..1275169-1554WP_180837176.1EAL domain-containing protein-
GPJ68_RS060501275358..1275618+261WP_104651311.1type B 50S ribosomal protein L31-
GPJ68_RS060551275620..1275760+141WP_005125190.1type B 50S ribosomal protein L36-
GPJ68_RS060601275839..1276309-471WP_016152071.1YlaC family protein-
GPJ68_RS060651276426..1276977-552WP_103283555.1maltose O-acetyltransferase-
GPJ68_RS060701277158..1277376-219WP_002892050.1hemolysin expression modulator HhaToxin
GPJ68_RS060751277404..1277778-375WP_003021733.1Hha toxicity modulator TomBAntitoxin
GPJ68_RS060801278266..1281415-3150WP_016152073.1multidrug efflux RND transporter permease subunit-
GPJ68_RS060851281438..1282631-1194WP_047416860.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T144700 WP_002892050.1 NZ_CP046673:c1277376-1277158 [Citrobacter sp. 172116965]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T144700 NZ_CP062228:c2227872-2227618 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT144700 WP_003021733.1 NZ_CP046673:c1277778-1277404 [Citrobacter sp. 172116965]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT144700 NZ_CP062228:c2228120-2227869 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2P8K6F2

Antitoxin

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Source
ID
Structure
AlphaFold DBR8WZW8

References