Detailed information of TA system TA144699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 655071..655590
• Replicon: chromosome
• Accession: NZ_CP046673
• Organism: Citrobacter sp. 172116965

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPJ68_RS03180
• Protein ID: WP_016155559.1
• Coordinates: 655071..655352 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0V9JX71
• Locus tag: GPJ68_RS03185
• Protein ID: WP_016155558.1
• Coordinates: 655342..655590 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPJ68_RS03165	652073..652537	+	465	WP_016151476.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GPJ68_RS03170	652559..653080	-	522	WP_104651644.1	hypothetical protein	-
GPJ68_RS03175	653080..655044	-	1965	WP_104651645.1	type VI secretion system tip protein VgrG	-
GPJ68_RS03180	655071..655352	-	282	WP_016155559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPJ68_RS03185	655342..655590	-	249	WP_016155558.1	hypothetical protein	Antitoxin
GPJ68_RS03190	655663..655842	-	180	WP_049043256.1	hypothetical protein	-
GPJ68_RS03195	655968..656480	-	513	WP_180837117.1	hypothetical protein	-
GPJ68_RS03200	656509..658425	-	1917	Protein_626	type VI secretion system ATPase TssH	-
GPJ68_RS03205	658533..659741	+	1209	WP_001339175.1	IS4-like element ISVsa5 family transposase	-
GPJ68_RS03210	659757..659876	-	120	Protein_628	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11004.76 Da
• Isoelectric Point: 10.4466

>T144699 WP_016155559.1 NZ_CP046673:c655352-655071 [Citrobacter sp. 172116965]
MTYNLEFLDVALKEWRKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Nucleotide

• Length: 282 bp

>T144699 NZ_CP062228:2217424-2217798 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8987.28 Da
• Isoelectric Point: 4.7513

>AT144699 WP_016155558.1 NZ_CP046673:c655590-655342 [Citrobacter sp. 172116965]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIKVSLN
DL

Nucleotide

• Length: 249 bp

>AT144699 NZ_CP062228:2216967-2217335 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0V9JX71