Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2807386..2808989 Replicon chromosome
Accession NZ_CP046672
Organism Raoultella ornithinolytica strain 172117885

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Y6GHD8
Locus tag GPJ66_RS13260 Protein ID WP_015584335.1
Coordinates 2807386..2808717 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A808YAX5
Locus tag GPJ66_RS13265 Protein ID WP_032717448.1
Coordinates 2808717..2808989 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ66_RS13245 2803260..2804174 - 915 WP_015584333.1 branched-chain amino acid ABC transporter permease -
GPJ66_RS13250 2804274..2805332 - 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
GPJ66_RS13255 2806047..2807453 + 1407 WP_048023687.1 glycoside hydrolase family 10 protein -
GPJ66_RS13260 2807386..2808717 - 1332 WP_015584335.1 type II toxin-antitoxin system HipA family toxin Toxin
GPJ66_RS13265 2808717..2808989 - 273 WP_032717448.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
GPJ66_RS13270 2809192..2809746 - 555 WP_004861926.1 RNA polymerase sigma factor -
GPJ66_RS13275 2809752..2810177 - 426 WP_032724724.1 hypothetical protein -
GPJ66_RS13280 2810310..2811263 - 954 WP_004861921.1 hypothetical protein -
GPJ66_RS13285 2811477..2812109 - 633 WP_064359334.1 class I SAM-dependent methyltransferase -
GPJ66_RS13290 2812129..2813370 - 1242 WP_064359335.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49327.66 Da        Isoelectric Point: 6.7012

>T144695 WP_015584335.1 NZ_CP046672:c2808717-2807386 [Raoultella ornithinolytica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Download         Length: 1332 bp

>T144695 NZ_CP062228:c1344591-1344484 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10365.71 Da        Isoelectric Point: 5.7971

>AT144695 WP_032717448.1 NZ_CP046672:c2808989-2808717 [Raoultella ornithinolytica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Download         Length: 273 bp

>AT144695 NZ_CP062228:1344644-1344705 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6GHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A808YAX5

References