Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2467185..2468098 Replicon chromosome
Accession NZ_CP046671
Organism Raoultella ornithinolytica strain 193104922

Toxin (Protein)


Gene name - Uniprot ID A0A808Y4A8
Locus tag GPJ65_RS11540 Protein ID WP_015584188.1
Coordinates 2467185..2467658 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A808Y7A4
Locus tag GPJ65_RS11545 Protein ID WP_004862777.1
Coordinates 2467655..2468098 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ65_RS11515 2463224..2463832 - 609 WP_032724246.1 glutathione S-transferase family protein -
GPJ65_RS11520 2464074..2464979 + 906 WP_004862790.1 transcriptional regulator GcvA -
GPJ65_RS11525 2465007..2465912 - 906 WP_044349852.1 LysR family transcriptional regulator -
GPJ65_RS11530 2466015..2466332 + 318 WP_004862785.1 nuclear transport factor 2 family protein -
GPJ65_RS11535 2466325..2467104 + 780 WP_180850562.1 SDR family oxidoreductase -
GPJ65_RS11540 2467185..2467658 - 474 WP_015584188.1 RES domain-containing protein Toxin
GPJ65_RS11545 2467655..2468098 - 444 WP_004862777.1 DUF2384 domain-containing protein Antitoxin
GPJ65_RS11550 2468288..2468854 - 567 WP_015584190.1 DJ-1/PfpI family protein -
GPJ65_RS11555 2469252..2470034 + 783 WP_004862772.1 DUF3750 domain-containing protein -
GPJ65_RS11560 2470230..2471453 + 1224 WP_048025269.1 zinc metallochaperone GTPase ZigA -
GPJ65_RS11580 2472383..2472916 - 534 WP_088402600.1 acid resistance repetitive basic protein Asr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17524.82 Da        Isoelectric Point: 4.8081

>T144678 WP_015584188.1 NZ_CP046671:c2467658-2467185 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Download         Length: 474 bp

>T144678 NZ_CP062218:3279367-3279942 [Pseudomonas putida]
ATGAGGCATTCCCCCTTCACGGCCGTCTACGACGCATGCGTTCTCTATCCCGCTCCGCTGCGGGACTTCCTGATGTGGCT
GGGGCTGTCCGGTCGGTTCCGAGCGCGTTGGAGCCAAACCATTCACGAGGAGTGGAAACGCAACCTGCTGATCAATCGGC
CCGATCTCACCAGGGCGCAAGTTGACCGAACGTCTGACCTGATGGATCGTGCCATCCCCGATGGATTGGTAGAAGGGTAC
GAATCGCTCGCGGCCGGTCTGACCTTGCCAGATCCGGACGACCGCCACGTGCTGGCCGCCGCCATTCGCTGTGGGGCGAG
TGTGATCGTGACATTCAACCAGCGAGATTTCCCGAATGAGCTGCTGGCGCCCTACGGCGTCGAATCGCAGCATCCGGATG
AGTTCGTGGACAACTTGCTGGATCTGGATGCGGCTGCAGTCGTCTCGGCCGCACAGCGCCAGCGCGCCCAACTGAGGAAC
CCGACGATCGACGTCGATCGCTATCTCGATATCTTGCTGCGCCAAGGCCTGGTCCAGACCACCAAGGTGCTTGCCGGCTA
CCGCACTATCCTCTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16190.45 Da        Isoelectric Point: 4.9405

>AT144678 WP_004862777.1 NZ_CP046671:c2468098-2467655 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSILDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT144678 NZ_CP062218:3278903-3279370 [Pseudomonas putida]
ATGACCGTTACTGCCCAATCCAAGATGACTCTGCCCGCCGAGGGTGAGGTGAAGGCAGCCGTGCAGGGGCAACGCGCCTT
GGCTGCCTACCTCGCGACGCAGTTTGAAACTCAGCACATCCAGATTTTCGATGACCAGAAGCAGGCACACCAAGTCGAGC
TGCCGACCTCGGCTTTGCGTTTGTTGGTGGACATCTTGGCCGAACTGGCCGACGGCAATGCTGTGAAGGTGGTGCCTGTC
CATGCCGAGCTGACAACACAGGAGGCCGCGGACCTGCTCAACGTGTCCCGTCCGCATTTCGTCAAGCTGCTCGAAGATGG
GGTGTTGGCGTTTCATCGGACTGGCAAGCACCGCCGGGTGAGGTTTGCCGACCTGATGCAGTACAAGGAGGCGCGTGAGC
GCGCCAGCGAGCAGGCGATGGCTGAACTCACACAGCAGTCGCAAGAGTTGGGAATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808Y4A8

Antitoxin

Source ID Structure
AlphaFold DB A0A808Y7A4

References