Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875328..875985 Replicon chromosome
Accession NZ_CP046671
Organism Raoultella ornithinolytica strain 193104922

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag GPJ65_RS04280 Protein ID WP_004867355.1
Coordinates 875575..875985 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag GPJ65_RS04275 Protein ID WP_004867358.1
Coordinates 875328..875594 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ65_RS04250 870463..871896 - 1434 WP_004867372.1 6-phospho-beta-glucosidase -
GPJ65_RS04255 872016..872744 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
GPJ65_RS04260 872794..873105 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
GPJ65_RS04265 873267..873926 + 660 WP_004867362.1 hemolysin III family protein -
GPJ65_RS04270 874048..875031 - 984 WP_088402302.1 tRNA-modifying protein YgfZ -
GPJ65_RS04275 875328..875594 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
GPJ65_RS04280 875575..875985 + 411 WP_004867355.1 protein YgfX Toxin
GPJ65_RS04285 875993..876514 - 522 WP_004867353.1 flavodoxin FldB -
GPJ65_RS04290 876693..877589 + 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
GPJ65_RS04295 877612..878325 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GPJ65_RS04300 878331..880064 + 1734 WP_088402300.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T144668 WP_004867355.1 NZ_CP046671:875575-875985 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T144668 NZ_CP062212:96293-96691 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT144668 WP_004867358.1 NZ_CP046671:875328-875594 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT144668 NZ_CP062212:96066-96293 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References