144652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4793718..4794234 Replicon chromosome
Accession NZ_CP046645
Organism Klebsiella pneumoniae strain EGKP3

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag GPU01_RS23120 Protein ID WP_004894697.1
Coordinates 4793718..4794002 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GPU01_RS23125 Protein ID WP_002886901.1
Coordinates 4793992..4794234 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPU01_RS23095 (GPU01_22770) 4789113..4789376 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
GPU01_RS23100 4789506..4789679 + 174 WP_002886906.1 hypothetical protein -
GPU01_RS23105 (GPU01_22775) 4789682..4790425 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
GPU01_RS23110 (GPU01_22780) 4790783..4792921 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
GPU01_RS23115 (GPU01_22785) 4793250..4793714 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GPU01_RS23120 (GPU01_22790) 4793718..4794002 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPU01_RS23125 (GPU01_22795) 4793992..4794234 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPU01_RS23130 (GPU01_22800) 4794312..4796222 - 1911 WP_023325426.1 PRD domain-containing protein -
GPU01_RS23135 (GPU01_22805) 4796245..4797399 - 1155 WP_004178372.1 lactonase family protein -
GPU01_RS23140 (GPU01_22810) 4797466..4798206 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T144652 WP_004894697.1 NZ_CP046645:c4794002-4793718 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T144652 NZ_CP062211:c2005167-2005060 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT144652 WP_002886901.1 NZ_CP046645:c4794234-4793992 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT144652 NZ_CP062211:2005215-2005281 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References