Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4723848..4724540 Replicon chromosome
Accession NZ_CP046645
Organism Klebsiella pneumoniae strain EGKP3

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GPU01_RS22805 Protein ID WP_172402701.1
Coordinates 4723848..4724162 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GPU01_RS22810 Protein ID WP_172402700.1
Coordinates 4724205..4724540 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPU01_RS22775 (GPU01_22445) 4719663..4720790 + 1128 WP_023325431.1 PAAR domain-containing protein -
GPU01_RS22780 (GPU01_22450) 4720810..4721043 + 234 WP_014908049.1 hypothetical protein -
GPU01_RS22785 (GPU01_22455) 4721189..4721323 + 135 Protein_4468 transposase -
GPU01_RS22790 (GPU01_22460) 4721336..4721446 - 111 Protein_4469 DUF4102 domain-containing protein -
GPU01_RS22795 (GPU01_22465) 4721821..4722828 - 1008 WP_040148942.1 restriction endonuclease -
GPU01_RS22800 (GPU01_22470) 4722905..4723735 - 831 WP_040148943.1 DUF4942 domain-containing protein -
GPU01_RS22805 (GPU01_22475) 4723848..4724162 - 315 WP_172402701.1 TA system toxin CbtA family protein Toxin
GPU01_RS22810 (GPU01_22480) 4724205..4724540 - 336 WP_172402700.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GPU01_RS22815 (GPU01_22485) 4724541..4725011 - 471 WP_040148946.1 DNA repair protein RadC -
GPU01_RS22820 (GPU01_22490) 4725082..4725903 - 822 WP_040148947.1 DUF932 domain-containing protein -
GPU01_RS22825 (GPU01_22495) 4726002..4726214 - 213 WP_040148948.1 hypothetical protein -
GPU01_RS22830 (GPU01_22500) 4726288..4726644 - 357 WP_223366209.1 hypothetical protein -
GPU01_RS22835 (GPU01_22505) 4726717..4727181 - 465 WP_040148963.1 hypothetical protein -
GPU01_RS22840 (GPU01_22510) 4728053..4729507 + 1455 WP_072042785.1 YfjI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4715536..4741689 26153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(6-103)

Antitoxin

Antitoxin CbeA

(12-110)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11821.33 Da        Isoelectric Point: 6.4783

>T144651 WP_172402701.1 NZ_CP046645:c4724162-4723848 [Klebsiella pneumoniae]
ISTVPAKESVSSRLSPVQVWQQLLTYLLNHHYGLTLNDTPFHNDTAIQEHIEAGIALADAVNFLVERYELVRTDRKGFTW
QDQTPFLTTTDILRARRATGIINT

Download         Length: 315 bp

>T144651 NZ_CP062211:1846421-1846804 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12458.29 Da        Isoelectric Point: 6.4455

>AT144651 WP_172402700.1 NZ_CP046645:c4724540-4724205 [Klebsiella pneumoniae]
MEVFMPFTLPNEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGEITPKQLQKLAQTFPLFISQLEAMLRSGELNSQQQ
HQVTIQLASLTCIADTRGSCGYVYISIYPTP

Download         Length: 336 bp

>AT144651 NZ_CP062211:1845960-1846340 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References