Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824702..825359 Replicon chromosome
Accession NZ_CP046645
Organism Klebsiella pneumoniae strain EGKP3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GPU01_RS04145 Protein ID WP_002916310.1
Coordinates 824949..825359 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GPU01_RS04140 Protein ID WP_002916312.1
Coordinates 824702..824968 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPU01_RS04115 (GPU01_04070) 819858..821291 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GPU01_RS04120 (GPU01_04075) 821410..822138 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GPU01_RS04125 (GPU01_04080) 822188..822499 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GPU01_RS04130 (GPU01_04085) 822663..823322 + 660 WP_004889817.1 hemolysin III family protein -
GPU01_RS04135 (GPU01_04090) 823473..824456 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GPU01_RS04140 (GPU01_04095) 824702..824968 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GPU01_RS04145 (GPU01_04100) 824949..825359 + 411 WP_002916310.1 protein YgfX Toxin
GPU01_RS04150 (GPU01_04105) 825366..825887 - 522 WP_004144730.1 flavodoxin FldB -
GPU01_RS04155 (GPU01_04110) 825988..826884 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GPU01_RS04160 (GPU01_04115) 826907..827620 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GPU01_RS04165 (GPU01_04120) 827626..829359 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T144638 WP_002916310.1 NZ_CP046645:824949-825359 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T144638 NZ_CP062204:c4639349-4639176 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT144638 WP_002916312.1 NZ_CP046645:824702-824968 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT144638 NZ_CP062204:c4639673-4639377 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References