Detailed information of TA system TA144632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 64034..64528
• Replicon: plasmid p1_CNU_G6
• Accession: NZ_CP046630
• Organism: Streptococcus equinus strain CNU G6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPA00_RS09595
• Protein ID: WP_157328647.1
• Coordinates: 64034..64306 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPA00_RS09600
• Protein ID: WP_157328649.1
• Coordinates: 64307..64528 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPA00_RS09570	59059..59385	-	327	WP_157328640.1	TrbC/VirB2 family protein	-
GPA00_RS09575	59455..61332	-	1878	WP_157328642.1	ATP-dependent Clp protease ATP-binding subunit	-
GPA00_RS09580	61332..61691	-	360	WP_157328644.1	hypothetical protein	-
GPA00_RS09585	62959..63537	-	579	WP_157328645.1	GTP pyrophosphokinase	-
GPA00_RS09590	63603..63899	-	297	WP_166044397.1	hypothetical protein	-
GPA00_RS09595	64034..64306	-	273	WP_157328647.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPA00_RS09600	64307..64528	-	222	WP_157328649.1	translation repressor RelB	Antitoxin
GPA00_RS09605	64605..65150	-	546	WP_157328651.1	hypothetical protein	-
GPA00_RS09610	65353..65835	-	483	WP_157328653.1	hypothetical protein	-
GPA00_RS09615	65902..66045	-	144	WP_157328655.1	hypothetical protein	-
GPA00_RS09620	66080..66451	-	372	WP_157328658.1	hypothetical protein	-
GPA00_RS09625	66482..66706	-	225	WP_157328660.1	hypothetical protein	-
GPA00_RS09630	66703..66942	-	240	WP_157328662.1	hypothetical protein	-
GPA00_RS09635	67026..67235	-	210	WP_157328664.1	hypothetical protein	-
GPA00_RS09640	67254..67565	-	312	WP_157328665.1	hypothetical protein	-
GPA00_RS09645	67634..67831	-	198	WP_157328667.1	hypothetical protein	-
GPA00_RS09650	67868..68557	-	690	WP_157328669.1	DNA repair protein RadC	-
GPA00_RS09655	68612..68947	-	336	WP_157328671.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..86344	86344

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10650.26 Da
• Isoelectric Point: 10.2622

>T144632 WP_157328647.1 NZ_CP046630:c64306-64034 [Streptococcus equinus]
MYHVEYSKRAKKQIKKLDKSVQRLLFAWIDKNLEGCDNPRQHGKGLTANRANQWRYRIGNYRLICDIQDDKAVILALEFG
HRSTIYVRGE

Nucleotide

• Length: 273 bp

>T144632 NZ_CP062204:2793949-2794056 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8494.48 Da
• Isoelectric Point: 4.3690

>AT144632 WP_157328649.1 NZ_CP046630:c64528-64307 [Streptococcus equinus]
MSTITVRLNQKEEELFKGYSELSGESISTLLKKALINNIEDELDYKVYQEAYQEYQKDSETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT144632 NZ_CP062204:c2793899-2793836 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT