Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1080900..1081425 Replicon chromosome
Accession NZ_CP046623
Organism Streptomyces murinus strain CR-43

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GO605_RS05020 Protein ID WP_182776590.1
Coordinates 1080900..1081163 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GO605_RS05025 Protein ID WP_182776591.1
Coordinates 1081156..1081425 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO605_RS04990 (GO605_05025) 1076893..1077429 + 537 WP_182776584.1 NUDIX domain-containing protein -
GO605_RS04995 (GO605_05030) 1077426..1077887 + 462 WP_182776585.1 hypothetical protein -
GO605_RS05000 (GO605_05035) 1077906..1078448 - 543 WP_182776586.1 hypothetical protein -
GO605_RS05005 (GO605_05040) 1078519..1079055 - 537 WP_182776587.1 hypothetical protein -
GO605_RS05010 (GO605_05045) 1079446..1080180 - 735 WP_182776588.1 HEAT repeat domain-containing protein -
GO605_RS05015 (GO605_05050) 1080177..1080557 - 381 WP_182776589.1 CPCC family cysteine-rich protein -
GO605_RS05020 (GO605_05055) 1080900..1081163 - 264 WP_182776590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GO605_RS05025 (GO605_05060) 1081156..1081425 - 270 WP_182776591.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GO605_RS05030 (GO605_05065) 1081595..1082827 - 1233 WP_182776592.1 serpin family protein -
GO605_RS05035 (GO605_05070) 1083087..1083839 + 753 WP_128791519.1 GntR family transcriptional regulator -
GO605_RS05040 (GO605_05075) 1084220..1084411 + 192 WP_172427620.1 SPOR domain-containing protein -
GO605_RS05045 (GO605_05080) 1084584..1084994 + 411 WP_182778997.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
GO605_RS05050 (GO605_05085) 1085262..1085669 + 408 WP_128791520.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1064297..1096049 31752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10107.58 Da        Isoelectric Point: 8.5990

>T144631 WP_182776590.1 NZ_CP046623:c1081163-1080900 [Streptomyces murinus]
VSDHRTVFHPEAQAELRKIPRDMALRILAKLTELETDPLGFNTTPLVSRPERRRLRVGDYRVVYTIDNGELVVWVIHVGH
RSTVYET

Download         Length: 264 bp

>T144631 NZ_CP062204:2793414-2793521 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10275.71 Da        Isoelectric Point: 4.6361

>AT144631 WP_182776591.1 NZ_CP046623:c1081425-1081156 [Streptomyces murinus]
MTQPLPIESIRDVRAHLAEVVERADRDDTPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEEI
MRETLARGE

Download         Length: 270 bp

>AT144631 NZ_CP062204:c2793361-2793300 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References