144627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 471484..472097 Replicon chromosome
Accession NZ_CP046621
Organism Pseudomonas alkylphenolica strain Neo

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GPJ81_RS02215 Protein ID WP_157190834.1
Coordinates 471484..471663 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GPJ81_RS02220 Protein ID WP_157190835.1
Coordinates 471690..472097 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ81_RS02200 467782..468972 + 1191 WP_157190831.1 MFS transporter -
GPJ81_RS02205 468977..470125 - 1149 WP_157190832.1 hypothetical protein -
GPJ81_RS02210 470300..471307 + 1008 WP_157190833.1 ADP-glyceromanno-heptose 6-epimerase -
GPJ81_RS02215 471484..471663 + 180 WP_157190834.1 type II toxin-antitoxin system HicA family toxin Toxin
GPJ81_RS02220 471690..472097 + 408 WP_157190835.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GPJ81_RS02230 472341..472583 - 243 WP_157190836.1 hypothetical protein -
GPJ81_RS02235 472608..472988 - 381 WP_157190837.1 hypothetical protein -
GPJ81_RS02240 473007..473213 - 207 WP_038605723.1 helix-turn-helix transcriptional regulator -
GPJ81_RS02245 473223..473801 - 579 WP_157190838.1 hypothetical protein -
GPJ81_RS02250 474320..474679 + 360 WP_038605728.1 multidrug/spermidine efflux SMR transporter subunit MdtJ -
GPJ81_RS02255 474673..475002 + 330 WP_157190839.1 multidrug/spermidine efflux SMR transporter subunit MdtI -
GPJ81_RS02260 475242..476462 - 1221 WP_157190840.1 methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6703.87 Da        Isoelectric Point: 11.3085

>T144627 WP_157190834.1 NZ_CP046621:471484-471663 [Pseudomonas alkylphenolica]
MNSRQLIAQIEADGWYLVRIRGSHHHFKHPVKPGLVTIPHPKKDLLARTASSILKQAQL

Download         Length: 180 bp

>T144627 NZ_CP062204:1909765-1910019 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14594.75 Da        Isoelectric Point: 4.6972

>AT144627 WP_157190835.1 NZ_CP046621:471690-472097 [Pseudomonas alkylphenolica]
MLFPIAILPGDEQHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHLEMLAQDGQMIPKASKVTTHATNPAFAGCTWAV
IDIDITKYLGKAEKLNITLPAYLLSRIDAYVKNHPEQKSRSGFLAEAALKVLQSS

Download         Length: 408 bp

>AT144627 NZ_CP062204:1909517-1909768 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References