Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-AbrB |
| Location | 1817657..1818263 | Replicon | chromosome |
| Accession | NZ_CP046616 | ||
| Organism | Sulfolobus islandicus strain HVE 10/4 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | M9UBU6 |
| Locus tag | GO599_RS09775 | Protein ID | WP_014513042.1 |
| Coordinates | 1817657..1818061 (-) | Length | 135 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | M9UBQ9 |
| Locus tag | GO599_RS09780 | Protein ID | WP_009989091.1 |
| Coordinates | 1818042..1818263 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GO599_RS09740 (GO599_09620) | 1812843..1813751 | - | 909 | WP_014513045.1 | dihydrodipicolinate synthase family protein | - |
| GO599_RS09745 (GO599_09625) | 1813789..1814550 | - | 762 | WP_014513044.1 | ZIP family metal transporter | - |
| GO599_RS09750 (GO599_09630) | 1814698..1814880 | - | 183 | WP_009990866.1 | hypothetical protein | - |
| GO599_RS09755 (GO599_09640) | 1815715..1816494 | + | 780 | WP_014513043.1 | DMT family transporter | - |
| GO599_RS09760 | 1816871..1817032 | + | 162 | WP_272584811.1 | hypothetical protein | - |
| GO599_RS09765 (GO599_09645) | 1817025..1817132 | - | 108 | Protein_1942 | IS110 family transposase | - |
| GO599_RS09770 (GO599_09650) | 1817252..1817461 | + | 210 | Protein_1943 | transposase | - |
| GO599_RS09775 (GO599_09655) | 1817657..1818061 | - | 405 | WP_014513042.1 | PIN domain-containing protein | Toxin |
| GO599_RS09780 (GO599_09660) | 1818042..1818263 | - | 222 | WP_009989091.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| GO599_RS09785 (GO599_09665) | 1818733..1818987 | + | 255 | WP_272584813.1 | hypothetical protein | - |
| GO599_RS09790 (GO599_09670) | 1819046..1819333 | + | 288 | WP_015581508.1 | EamA family transporter | - |
| GO599_RS09795 (GO599_09675) | 1819388..1820659 | + | 1272 | WP_014513041.1 | MFS transporter | - |
| GO599_RS09800 (GO599_09680) | 1820778..1821443 | + | 666 | WP_014513040.1 | helix-turn-helix domain-containing protein | - |
| GO599_RS09805 (GO599_09685) | 1821440..1821826 | - | 387 | WP_014513039.1 | hypothetical protein | - |
| GO599_RS09810 (GO599_09690) | 1821823..1822440 | - | 618 | WP_012712231.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 15441.05 Da Isoelectric Point: 5.2947
>T144613 WP_014513042.1 NZ_CP046616:c1818061-1817657 [Sulfolobus islandicus]
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLKKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS
VEKAIVDTNVIIYDYVEDSEYHKRAEELLDSLDRWVIPVIVVHEIMWFLKGMKLEDKVDDVLAYIRSEKAEVVCDCTDNV
TDAIGVLKKEKLPLVSYKDMVILSHAIREKLPLATFDRKLSKIAKKYSVSLLQS
Download Length: 405 bp
>T144613 NZ_CP062203:3284588-3284974 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCACTAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCACTAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8267.50 Da Isoelectric Point: 9.6908
>AT144613 WP_009989091.1 NZ_CP046616:c1818263-1818042 [Sulfolobus islandicus]
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS
MERVKVTRNYQITIPASARSKINIKEGDILEVYLNGDEIVLRKVKTERPRIRLGSKLSLGDIEEAIERGEGNS
Download Length: 222 bp
>AT144613 NZ_CP062203:3284964-3285293 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|