Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/HTH_10(toxin) |
| Location | 603484..604463 | Replicon | chromosome |
| Accession | NZ_CP046616 | ||
| Organism | Sulfolobus islandicus strain HVE 10/4 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | M9U7R2 |
| Locus tag | GO599_RS03295 | Protein ID | WP_014512230.1 |
| Coordinates | 603484..604098 (-) | Length | 205 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | M9U539 |
| Locus tag | GO599_RS03300 | Protein ID | WP_014512229.1 |
| Coordinates | 604116..604463 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GO599_RS03250 (GO599_03175) | 598621..599445 | - | 825 | WP_014512237.1 | DMT family transporter | - |
| GO599_RS03255 (GO599_03180) | 599465..599686 | - | 222 | WP_014512236.1 | hypothetical protein | - |
| GO599_RS03260 | 599753..599947 | - | 195 | WP_193385885.1 | hypothetical protein | - |
| GO599_RS03265 (GO599_03185) | 600044..600643 | - | 600 | WP_014512235.1 | DUF2249 domain-containing protein | - |
| GO599_RS03270 (GO599_03190) | 600891..601118 | + | 228 | WP_014512234.1 | hypothetical protein | - |
| GO599_RS03275 (GO599_03195) | 601099..601422 | - | 324 | WP_014512233.1 | hypothetical protein | - |
| GO599_RS03280 (GO599_03200) | 601426..602190 | - | 765 | WP_014512232.1 | plastocyanin/azurin family copper-binding protein | - |
| GO599_RS03285 | 602846..603040 | - | 195 | WP_014513669.1 | hypothetical protein | - |
| GO599_RS03290 (GO599_03215) | 603165..603440 | + | 276 | WP_014512231.1 | hypothetical protein | - |
| GO599_RS03295 (GO599_03220) | 603484..604098 | - | 615 | WP_014512230.1 | helix-turn-helix domain-containing protein | Toxin |
| GO599_RS03300 (GO599_03225) | 604116..604463 | - | 348 | WP_014512229.1 | DUF488 domain-containing protein | Antitoxin |
| GO599_RS03305 (GO599_03230) | 604532..604762 | - | 231 | WP_014512228.1 | C2H2-type zinc finger protein | - |
| GO599_RS03310 (GO599_03235) | 604853..604969 | + | 117 | Protein_653 | iron-sulfur cluster assembly protein | - |
| GO599_RS03315 (GO599_03240) | 604979..606175 | - | 1197 | WP_272584891.1 | transposase | - |
| GO599_RS03320 | 606320..606442 | + | 123 | WP_237702665.1 | hypothetical protein | - |
| GO599_RS03325 (GO599_03250) | 606540..606971 | - | 432 | WP_014512226.1 | universal stress protein | - |
| GO599_RS03330 (GO599_03255) | 607289..608227 | - | 939 | WP_014512225.1 | dipeptidase | - |
| GO599_RS03335 (GO599_03260) | 608172..609368 | - | 1197 | WP_014512224.1 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 604979..606175 | 1196 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 205 a.a. Molecular weight: 23353.44 Da Isoelectric Point: 9.4585
>T144612 WP_014512230.1 NZ_CP046616:c604098-603484 [Sulfolobus islandicus]
MLKSPFEVTILIEDHPCEVMGVISSTGLKATVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSIKVLKFNDSKVWVRTK
GCSVCKILYSSNVVVEKIKVIKERTLLYTLLVPNTIAFKEFLANLTSQRIKFTVLSTYEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEIMRRALRKVVKYYLDKVG
MLKSPFEVTILIEDHPCEVMGVISSTGLKATVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSIKVLKFNDSKVWVRTK
GCSVCKILYSSNVVVEKIKVIKERTLLYTLLVPNTIAFKEFLANLTSQRIKFTVLSTYEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEIMRRALRKVVKYYLDKVG
Download Length: 615 bp
>T144612 NZ_CP062203:c3012270-3011893 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATAACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATAACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13678.98 Da Isoelectric Point: 9.8667
>AT144612 WP_014512229.1 NZ_CP046616:c604463-604116 [Sulfolobus islandicus]
MIKIKRVYDPIEKDDGLRVLVDRLWPRGIGKNKVDLWLKDIAPSDELRKWYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKE
MIKIKRVYDPIEKDDGLRVLVDRLWPRGIGKNKVDLWLKDIAPSDELRKWYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKE
Download Length: 348 bp
>AT144612 NZ_CP062203:c3012727-3012359 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|