Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 586412..587018 Replicon chromosome
Accession NZ_CP046616
Organism Sulfolobus islandicus strain HVE 10/4

Toxin (Protein)


Gene name vapC Uniprot ID F0NNP3
Locus tag GO599_RS03190 Protein ID WP_014512246.1
Coordinates 586626..587018 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F0NNP4
Locus tag GO599_RS03185 Protein ID WP_014512247.1
Coordinates 586412..586636 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO599_RS03170 (GO599_03095) 582350..583114 + 765 WP_014512249.1 enoyl-CoA hydratase/isomerase family protein -
GO599_RS03175 (GO599_03100) 583117..585383 + 2267 Protein_626 xanthine dehydrogenase family protein molybdopterin-binding subunit -
GO599_RS03180 (GO599_03105) 585593..586296 + 704 Protein_627 helix-turn-helix domain-containing protein -
GO599_RS03185 (GO599_03110) 586412..586636 + 225 WP_014512247.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
GO599_RS03190 (GO599_03115) 586626..587018 + 393 WP_014512246.1 type II toxin-antitoxin system VapC family toxin Toxin
GO599_RS03195 (GO599_03120) 587344..587820 + 477 Protein_630 cytochrome b558/566 subunit B -
GO599_RS03200 (GO599_03125) 588571..589146 + 576 WP_014512244.1 XdhC family protein -
GO599_RS03205 (GO599_03130) 589253..590584 + 1332 WP_014512243.1 APC family permease -
GO599_RS03210 (GO599_03135) 590574..591548 - 975 WP_014512242.1 glycosyltransferase family A protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(9-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-48)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15015.68 Da        Isoelectric Point: 8.2956

>T144611 WP_014512246.1 NZ_CP046616:586626-587018 [Sulfolobus islandicus]
MKDKEFLFDASALYSLLDYVDKVDVKKIHILTLTLYEVGNVIWKEYYIHKKVKDPITLSTLFHKLMRKLNVVEDPPLDGV
MRIAVERSLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T144611 NZ_CP062203:2839997-2840104 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8883.21 Da        Isoelectric Point: 4.8365

>AT144611 WP_014512247.1 NZ_CP046616:586412-586636 [Sulfolobus islandicus]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIAMRIKELMRDVSEDDWVWAVRESRDER

Download         Length: 225 bp

>AT144611 NZ_CP062203:c2839947-2839884 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0NNP3

Antitoxin

Source ID Structure
AlphaFold DB F0NNP4

References