Detailed information of TA system TA144607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1901424..1902033
• Replicon: chromosome
• Accession: NZ_CP046615
• Organism: Sulfolobus acidocaldarius DSM 639

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M1IXF9
• Locus tag: GO597_RS10350
• Protein ID: WP_011278690.1
• Coordinates: 1901638..1902033 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1J7H5
• Locus tag: GO597_RS10345
• Protein ID: WP_011278689.1
• Coordinates: 1901424..1901648 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO597_RS10345 (GO597_10265)	1901424..1901648	+	225	WP_011278689.1	hypothetical protein	Antitoxin
GO597_RS10350 (GO597_10270)	1901638..1902033	+	396	WP_011278690.1	twitching motility protein PilT	Toxin
GO597_RS10355 (GO597_10275)	1902515..1903405	-	891	WP_015385703.1	DUF1177 domain-containing protein	-
GO597_RS10360 (GO597_10280)	1903402..1904649	-	1248	WP_011278692.1	FAD-binding oxidoreductase	-
GO597_RS10365 (GO597_10285)	1904920..1905174	-	255	WP_015385704.1	hypothetical protein	-
GO597_RS10370	1905443..1906633	-	1191	WP_011278693.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (8-116)

Antitoxin

• Putative antitoxin VapB3-like (1-74)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14959.46 Da
• Isoelectric Point: 5.7407

>T144607 WP_011278690.1 NZ_CP046615:1901638-1902033 [Sulfolobus acidocaldarius DSM 639]
MRGKFLFDASAIYPLIKFVDKVDLKNIYILHLTLYEVGNAIWKDAFLHGRIKNAKEVALLFQQLMGEFNIIDDPPLDEVI
GIAISKGITYYDASYVYVSAKEKLILVSNDKELISKGNTISFNEFMEKYLA

Nucleotide

• Length: 396 bp

>T144607 NZ_CP062203:2170874-2170977 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8878.21 Da
• Isoelectric Point: 8.7436

>AT144607 WP_011278689.1 NZ_CP046615:1901424-1901648 [Sulfolobus acidocaldarius DSM 639]
MSDVISVRVRKELKRRAEELGINLREVVERALEEAIRKKEMERVRTIAKKIQENMQGISEEEWAQLVRESRDER

Nucleotide

• Length: 225 bp

>AT144607 NZ_CP062203:c2171015-2170744 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: M1IXF9

Antitoxin

• AlphaFold DB: M1J7H5