Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 1901424..1902033 | Replicon | chromosome |
| Accession | NZ_CP046615 | ||
| Organism | Sulfolobus acidocaldarius DSM 639 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | M1IXF9 |
| Locus tag | GO597_RS10350 | Protein ID | WP_011278690.1 |
| Coordinates | 1901638..1902033 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | M1J7H5 |
| Locus tag | GO597_RS10345 | Protein ID | WP_011278689.1 |
| Coordinates | 1901424..1901648 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GO597_RS10345 (GO597_10265) | 1901424..1901648 | + | 225 | WP_011278689.1 | hypothetical protein | Antitoxin |
| GO597_RS10350 (GO597_10270) | 1901638..1902033 | + | 396 | WP_011278690.1 | twitching motility protein PilT | Toxin |
| GO597_RS10355 (GO597_10275) | 1902515..1903405 | - | 891 | WP_015385703.1 | DUF1177 domain-containing protein | - |
| GO597_RS10360 (GO597_10280) | 1903402..1904649 | - | 1248 | WP_011278692.1 | FAD-binding oxidoreductase | - |
| GO597_RS10365 (GO597_10285) | 1904920..1905174 | - | 255 | WP_015385704.1 | hypothetical protein | - |
| GO597_RS10370 | 1905443..1906633 | - | 1191 | WP_011278693.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14959.46 Da Isoelectric Point: 5.7407
>T144607 WP_011278690.1 NZ_CP046615:1901638-1902033 [Sulfolobus acidocaldarius DSM 639]
MRGKFLFDASAIYPLIKFVDKVDLKNIYILHLTLYEVGNAIWKDAFLHGRIKNAKEVALLFQQLMGEFNIIDDPPLDEVI
GIAISKGITYYDASYVYVSAKEKLILVSNDKELISKGNTISFNEFMEKYLA
MRGKFLFDASAIYPLIKFVDKVDLKNIYILHLTLYEVGNAIWKDAFLHGRIKNAKEVALLFQQLMGEFNIIDDPPLDEVI
GIAISKGITYYDASYVYVSAKEKLILVSNDKELISKGNTISFNEFMEKYLA
Download Length: 396 bp
>T144607 NZ_CP062203:2170874-2170977 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 75 a.a. Molecular weight: 8878.21 Da Isoelectric Point: 8.7436
>AT144607 WP_011278689.1 NZ_CP046615:1901424-1901648 [Sulfolobus acidocaldarius DSM 639]
MSDVISVRVRKELKRRAEELGINLREVVERALEEAIRKKEMERVRTIAKKIQENMQGISEEEWAQLVRESRDER
MSDVISVRVRKELKRRAEELGINLREVVERALEEAIRKKEMERVRTIAKKIQENMQGISEEEWAQLVRESRDER
Download Length: 225 bp
>AT144607 NZ_CP062203:c2171015-2170744 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|