Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5138506..5140187 Replicon chromosome
Accession NZ_CP046612
Organism Klebsiella pneumoniae strain WCGKP294

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag GPJ73_RS25030 Protein ID WP_002885155.1
Coordinates 5138506..5139423 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag GPJ73_RS25035 Protein ID WP_004177809.1
Coordinates 5139429..5140187 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ73_RS25010 5133812..5135332 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
GPJ73_RS25015 5135329..5136327 + 999 WP_002885172.1 ribose ABC transporter permease -
GPJ73_RS25020 5136358..5137299 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
GPJ73_RS25025 5137374..5138381 + 1008 WP_004177805.1 carbohydrate kinase family protein -
GPJ73_RS25030 5138506..5139423 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GPJ73_RS25035 5139429..5140187 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GPJ73_RS25040 5140273..5141001 - 729 WP_004177810.1 response regulator transcription factor -
GPJ73_RS25045 5141274..5143421 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
GPJ73_RS25050 5143651..5144337 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T144601 WP_002885155.1 NZ_CP046612:c5139423-5138506 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T144601 NZ_CP062196:1576281-1576550 [Plesiomonas shigelloides]
ATGAGTGAAAGGCTATTGTGTTGGACTGATGAGTCTTGGGATGACTATATTTACTGGCAATCTCAGGATAAGAAAACTTT
AAAAAGAATCAATAAGTTAATTATTGATGTTAAACGCACGCCGTTTGAAGGCATCGGAAAGCCTGAAGCCTTGAGAGAAA
ACCTGTCAGGATTCTGGTCTCGCCGCATAGATGATACAAACCGTTTAGTCTATGCGGTTGATGACCTATCAATTACCATC
ATTTCTTGTCGTTATCATTATCAAGCGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT144601 WP_004177809.1 NZ_CP046612:c5140187-5139429 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT144601 NZ_CP062196:1576034-1576288 [Plesiomonas shigelloides]
ATGAGAATCGTATCCTTTACTGAAGCTCGTAACAGCTTGAAATCAGTACTTGATTCAGTTGTAAACGATGCAGATACAAC
CATCATTACTCGCCGTGATGCGGATGATGCAGTTGTGATGTCTCTAGATTATTACAATAGCCTGATGGAAACTGTTCACT
TGTTGCGATCCCCCGCGAACGCAGAGCATTTGAACCGTTCTATAGCTCAATTTAAAGCTGGTCGAGTCACGCAGCGAGAG
TTGAAGGATGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References