Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4885316..4886019 Replicon chromosome
Accession NZ_CP046612
Organism Klebsiella pneumoniae strain WCGKP294

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag GPJ73_RS23845 Protein ID WP_071994632.1
Coordinates 4885316..4885657 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag GPJ73_RS23850 Protein ID WP_032434296.1
Coordinates 4885678..4886019 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ73_RS23835 4881631..4882500 + 870 WP_023317468.1 HNH endonuclease -
GPJ73_RS23840 4883091..4885124 + 2034 WP_050598589.1 hypothetical protein -
GPJ73_RS23845 4885316..4885657 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
GPJ73_RS23850 4885678..4886019 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GPJ73_RS23855 4886030..4886572 - 543 WP_032434298.1 DNA repair protein RadC -
GPJ73_RS23860 4886585..4887025 - 441 WP_032434300.1 antirestriction protein -
GPJ73_RS23865 4887056..4887877 - 822 WP_032434301.1 DUF945 domain-containing protein -
GPJ73_RS23870 4887997..4888470 - 474 WP_032434303.1 hypothetical protein -
GPJ73_RS23875 4888542..4888994 - 453 WP_032410767.1 hypothetical protein -
GPJ73_RS23880 4889030..4889746 - 717 WP_032434305.1 WYL domain-containing protein -
GPJ73_RS23885 4889990..4890864 - 875 Protein_4744 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T144599 WP_071994632.1 NZ_CP046612:c4885657-4885316 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

>T144599 NZ_CP062167:c3742887-3742465 [Aureimonas sp. OT7]
ATGATCGTTCTGGATACCAATGTCGTCTCCGAAGCGATGAAGCCGGAGCCGGACTCCGCCGTGCGCGACTGGCTGGACGA
GCAGGCCGCCGAAACCCTCTATCTGTCCAGCGTCACCGTCGCGGAGCTGTTGTTCGGCATCGGGGCGCTGCCGGACGGAC
GGCGCAAACAGAAGCTCGCCGCCACGCTGGACGAACATCTTGCCCTGTTCGACGGTCGAATCCTCCCTTTCGATACGGAC
GCCGCCCGCCACTATGCCGACCTTGCCGTTGCGGCACGAAATGCGGGTAAGGGCTTTCCCACACCGGACGGCTATATCGC
TGCCATCGCCACCGCTCACGGCTTTTCGGTCGCCACCCGCGATGCCAGCGCCTTCAATGCGGCAGGCGTTCCGGTTATTG
ATCCTTGGACGGCACGGCACTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT144599 WP_032434296.1 NZ_CP046612:c4886019-4885678 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT144599 NZ_CP062167:c3743138-3742884 [Aureimonas sp. OT7]
ATGCCCGCCGTCACCATTCGCAACCTGTCCGAAGAGGCGCACCGCGCCCTCAAGGTGCGCGCGGCTCATCATGGTCGCAG
CGCCGAGGCCGAAATGCGCAATATTCTGGAAGCGGCGGTTCGACCAGCCGACCGCCTGCGCATCGGGTCCGCCCTGTCGG
CGCTGAGCCGAAAAGCCGGGCTGACCAATGCCGATTTCGAGTCCGTGGAACAGGCCCGTGACAGGACGCCCGCCAAGCCG
ATGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References