Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4214410..4215029 Replicon chromosome
Accession NZ_CP046612
Organism Klebsiella pneumoniae strain WCGKP294

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GPJ73_RS20670 Protein ID WP_002892050.1
Coordinates 4214811..4215029 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GPJ73_RS20665 Protein ID WP_002892066.1
Coordinates 4214410..4214784 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ73_RS20655 4209562..4210755 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GPJ73_RS20660 4210778..4213924 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GPJ73_RS20665 4214410..4214784 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GPJ73_RS20670 4214811..4215029 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GPJ73_RS20675 4215188..4215754 + 567 WP_002892030.1 maltose O-acetyltransferase -
GPJ73_RS29755 4215726..4215866 - 141 WP_004147370.1 hypothetical protein -
GPJ73_RS20680 4215887..4216357 + 471 WP_002892026.1 YlaC family protein -
GPJ73_RS20685 4216332..4217783 - 1452 WP_032435563.1 PLP-dependent aminotransferase family protein -
GPJ73_RS20690 4217884..4218582 + 699 WP_032435564.1 GNAT family N-acetyltransferase -
GPJ73_RS20695 4218579..4218719 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GPJ73_RS20700 4218719..4218982 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T144597 WP_002892050.1 NZ_CP046612:4214811-4215029 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T144597 NZ_CP062167:c2235641-2235384 [Aureimonas sp. OT7]
ATGAAAGCGATCAGCTACACCACGCGAGCGCTCCGGTCCCTGTCGAGAATGCCCCGCAACGTTGCGACCCGCATTCAAGC
GAAGGTTGAGCAATTCGCGGCTGACCCGGCATCACTCGCGAACAACGTGAAGGCGCTCAAGGGCGAGATATCGGGTACGT
ACCGCCTTCGTGTTGGTGACTATCGGGTGATCTTCAACGAGCATGGCGTCGTCCTTGTCGTCCTCAAGGTCGGCCACCGT
CGCGACATTTACGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT144597 WP_002892066.1 NZ_CP046612:4214410-4214784 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT144597 NZ_CP062167:c2235372-2235001 [Aureimonas sp. OT7]
ATGTCCGTCCAGTATATCACGACCCCGGCCGGCGAGACGCTCGCCGTGCTACCCAAGTCCGAGTACGAGGCCCTTATCGA
ACGCCTGGAAGATATCGTCGACTCCGCTGCCGCCGCCGACACCCTCGCAAGGATCAATGCAGGCGAAGAAGAATTAATCC
CGGCTGCCGTGGTCAAGCGCATCGTCGATGGCGAAAACAAGGTGCGCGTATGGCGCGAGCACCGTGGCATGAGCGTCACG
GCGCTGGCGAAGGCAAGCGGCCTGTCGCAAGCCTATGTGAGCCAGATCGAAAGCGGTGCGCGGGCTGCCCGCCCGGATAA
ACGGGCCGCAATCGCCGAAGCGCTCAACTTGGCCATCGACGACCTGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References