Detailed information of TA system TA144596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2830612..2832200
• Replicon: chromosome
• Accession: NZ_CP046612
• Organism: Klebsiella pneumoniae strain WCGKP294

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9J6RYF8
• Locus tag: GPJ73_RS14015
• Protein ID: WP_004892016.1
• Coordinates: 2830612..2831934 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GPJ73_RS14020
• Protein ID: WP_004176198.1
• Coordinates: 2831934..2832200 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPJ73_RS14000	2825668..2828169	+	2502	WP_032435337.1	fimbrial biogenesis outer membrane usher protein	-
GPJ73_RS14005	2828157..2829161	+	1005	WP_032435338.1	type 1 fimbrial protein	-
GPJ73_RS14010	2829303..2830595	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
GPJ73_RS14015	2830612..2831934	-	1323	WP_004892016.1	type II toxin-antitoxin system HipA family toxin	Toxin
GPJ73_RS14020	2831934..2832200	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
GPJ73_RS14025	2832587..2832913	-	327	WP_004184023.1	hydroxyisourate hydrolase	-
GPJ73_RS14030	2832910..2833410	-	501	WP_032435339.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
GPJ73_RS14035	2833388..2834767	-	1380	WP_004184021.1	purine permease	-
GPJ73_RS14040	2835113..2836267	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
GPJ73_RS14045	2836248..2837171	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T144596 WP_004892016.1 NZ_CP046612:c2831934-2830612 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T144596 NZ_CP062165:5127578-5127928 [Paenibacillus sp. JNUCC-31]
TTGATCGTAAAACGCGGTGATGTTTTTTTTGCGGATCTTTCTCCCGTTGTCGGTTCCGAGCAAGGCGGAGTCAGGCCGGT
TCTGGTCATCCAGAATGACATCGGCAACCGGTTTAGTCCTACTTGTATTGTGGCGGCGATCACCGCCCAGATCCAAAAGG
CAAAGCTGCCGACGCATGTGGAGATTGATGCGGCGGCACATGGCTTTGACCGGGACTCGGTTATTTTGCTCGAACAAATA
CGGACAATTGATAAGCAGAGGCTGACCGACAAGATTACCCATCTGGACGAGGAGACCATGAAACTGGTCAACGAAGCCTT
ACAGATCAGCTTGGGCTTAATCGATTTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT144596 WP_004176198.1 NZ_CP046612:c2832200-2831934 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT144596 NZ_CP062165:5127293-5127574 [Paenibacillus sp. JNUCC-31]
GTGGCCAACTTGCAGAACACCAAGCGGATCATGATCAGTTTGCCTGATTATCTTTTGCAGGAAGTGGATGGCATCGTAGC
GCTGGAGAATTCCAACCGCAGCGAATTGATTAGGCAGGCCATGAAGCTGTATTTGACGGAGCGTAAGAAACGTTACATCC
GTGAATCAATGCAGCGAGGGTACATGGAGATGGCGAAGATTAACCTCACCATGGCATCCGAGGCCTTTCACGCGGAGGAA
GATGCGGACAGCACTCTGGACCGCTTAGTTAGCGGGGTGTAG