Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842099..842756 Replicon chromosome
Accession NZ_CP046612
Organism Klebsiella pneumoniae strain WCGKP294

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GPJ73_RS04215 Protein ID WP_002916310.1
Coordinates 842346..842756 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GPJ73_RS04210 Protein ID WP_002916312.1
Coordinates 842099..842365 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPJ73_RS04185 837307..838740 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
GPJ73_RS04190 838859..839587 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GPJ73_RS04195 839637..839948 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GPJ73_RS04200 840112..840771 + 660 WP_004174454.1 hemolysin III family protein -
GPJ73_RS04205 840870..841853 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
GPJ73_RS04210 842099..842365 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GPJ73_RS04215 842346..842756 + 411 WP_002916310.1 protein YgfX Toxin
GPJ73_RS04220 842763..843284 - 522 WP_002916308.1 flavodoxin FldB -
GPJ73_RS04225 843385..844281 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GPJ73_RS04230 844304..845017 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GPJ73_RS04235 845023..846756 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T144586 WP_002916310.1 NZ_CP046612:842346-842756 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T144586 NZ_CP062161:c5704-5399 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT144586 WP_002916312.1 NZ_CP046612:842099-842365 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT144586 NZ_CP062161:c5924-5706 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References