Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 58622..59216 Replicon plasmid unnamed1
Accession NZ_CP046610
Organism Burkholderia contaminans strain XL73

Toxin (Protein)


Gene name PumA Uniprot ID A0A228JB64
Locus tag GON15_RS38205 Protein ID WP_027811055.1
Coordinates 58923..59216 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A228JAU5
Locus tag GON15_RS38200 Protein ID WP_027811056.1
Coordinates 58622..58921 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GON15_RS38180 53920..55986 - 2067 WP_027811059.1 type IV secretion system DNA-binding domain-containing protein -
GON15_RS38185 55979..56380 - 402 WP_027811058.1 hypothetical protein -
GON15_RS38190 57397..57900 + 504 WP_143277545.1 hypothetical protein -
GON15_RS38195 58148..58459 + 312 WP_027811057.1 hypothetical protein -
GON15_RS38200 58622..58921 - 300 WP_027811056.1 putative addiction module antidote protein Antitoxin
GON15_RS38205 58923..59216 - 294 WP_027811055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GON15_RS38210 59321..59464 - 144 WP_154233621.1 hypothetical protein -
GON15_RS38215 59521..59742 - 222 WP_027811054.1 DUF3717 domain-containing protein -
GON15_RS38220 59787..60338 - 552 WP_077186813.1 hypothetical protein -
GON15_RS38225 60313..60579 - 267 WP_027811052.1 hypothetical protein -
GON15_RS38230 61623..63752 - 2130 WP_039350079.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..152473 152473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10854.50 Da        Isoelectric Point: 10.6086

>T144580 WP_027811055.1 NZ_CP046610:c59216-58923 [Burkholderia contaminans]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDMKPVGAGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

>T144580 NZ_CP046610:c59216-58923 [Burkholderia contaminans]
ATGAGAATCGAGCAGACAGACGACTTCGCGAAATGGTTGCGCGGCCTACGCGATCACATCGCGCGCGCGCAGATCGCCAA
GCGGATTCAACGGCTCGCGCGCGGCCAATATGGGGACATGAAGCCGGTGGGTGCCGGAGTGAGCGAAATGCGCGTGCACG
TCGGCCCCGGCTATCGCGTCTACTTTGTCCAACGAGGCTCAACGCTCGTCGTCCTGCTATGCGGTGGCGACAAGTCAACG
CAGCAGCGCGACATTGAGCGTGCTATCGCGCTTTCGGCGCAATTGGGAGATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10716.01 Da        Isoelectric Point: 4.6364

>AT144580 WP_027811056.1 NZ_CP046610:c58921-58622 [Burkholderia contaminans]
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp

>AT144580 NZ_CP046610:c58921-58622 [Burkholderia contaminans]
ATGGGTATCAAGACAACGCCGTTCGATGCGGCCGAATACCTCGACACGCCCGAGGCGCAGGCCGAATATCTGCGGATTTC
GTTCGAGACCGGCGATTCCGCCGACATTCAGGAAGCCATCGGCACCGTGGCGCGTGCGCGTGGCATGACGCAGATTGCGC
GCGACGCGGGCGTCGGCCGCGAAAGCCTCTACAAAGCGCTGGACGAGCACGGCAACCCGGAATTCGCGACGATCCTGCGT
GTTGTGCGCGCGCTCGGCCTCACGTTGACCGTGACGACGCCCGTACACGAGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228JB64

Antitoxin

Source ID Structure
AlphaFold DB A0A228JAU5

References