Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3094365..3094884 Replicon chromosome
Accession NZ_CP046608
Organism Burkholderia contaminans strain XL73

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FLI5
Locus tag GON15_RS20385 Protein ID WP_039349649.1
Coordinates 3094365..3094646 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V2WFY1
Locus tag GON15_RS20390 Protein ID WP_039349647.1
Coordinates 3094636..3094884 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GON15_RS20365 3090020..3090718 - 699 WP_039349658.1 MgtC/SapB family protein -
GON15_RS20370 3090833..3091942 + 1110 WP_039349656.1 AGE family epimerase/isomerase -
GON15_RS20375 3091915..3093534 - 1620 WP_039349654.1 Tar ligand binding domain-containing protein -
GON15_RS20380 3093804..3094247 + 444 WP_011353771.1 PaaI family thioesterase -
GON15_RS20385 3094365..3094646 - 282 WP_039349649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GON15_RS20390 3094636..3094884 - 249 WP_039349647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GON15_RS20395 3095026..3096078 - 1053 WP_039349645.1 CoA transferase -
GON15_RS20400 3096262..3097452 - 1191 WP_039349643.1 2-methylaconitate cis-trans isomerase PrpF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.88 Da        Isoelectric Point: 10.7091

>T144577 WP_039349649.1 NZ_CP046608:c3094646-3094365 [Burkholderia contaminans]
MTFELAFLEPALKEWKKLDRTVRDQFKSRLAERLENPRIPSAKLQGHPDRYKIKLRSVGYRLVYEVRDSEVLVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T144577 NZ_CP062160:c3506707-3506333 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9031.44 Da        Isoelectric Point: 5.6792

>AT144577 WP_039349647.1 NZ_CP046608:c3094884-3094636 [Burkholderia contaminans]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADKRAKEKVVKVKLN
DL

Download         Length: 249 bp

>AT144577 NZ_CP062160:c3507128-3506754 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FLI5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2WFY1

References