Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2055859..2057609 Replicon chromosome
Accession NZ_CP046608
Organism Burkholderia contaminans strain XL73

Toxin (Protein)


Gene name doc Uniprot ID A0A1E3FSX8
Locus tag GON15_RS15825 Protein ID WP_039344096.1
Coordinates 2056713..2057609 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1E3FSY5
Locus tag GON15_RS15820 Protein ID WP_039344097.1
Coordinates 2055859..2056716 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GON15_RS15800 2051022..2052512 - 1491 WP_039344105.1 aldehyde dehydrogenase -
GON15_RS15805 2052585..2053412 - 828 WP_039344103.1 aspartate dehydrogenase -
GON15_RS15810 2053405..2055072 - 1668 WP_039344101.1 thiamine pyrophosphate-binding protein -
GON15_RS15815 2055065..2055862 - 798 WP_039344099.1 SDR family oxidoreductase -
GON15_RS15820 2055859..2056716 - 858 WP_039344097.1 IclR family transcriptional regulator Antitoxin
GON15_RS15825 2056713..2057609 - 897 WP_039344096.1 alpha/beta fold hydrolase Toxin
GON15_RS15830 2057628..2058155 - 528 WP_039344094.1 cupin domain-containing protein -
GON15_RS15835 2058193..2058963 - 771 WP_039344092.1 SDR family oxidoreductase -
GON15_RS15840 2058956..2060032 - 1077 WP_039344090.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
GON15_RS15845 2060085..2060396 - 312 WP_039344088.1 hypothetical protein -
GON15_RS15850 2060398..2060715 - 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
GON15_RS15855 2061160..2062239 + 1080 WP_039344086.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30700.99 Da        Isoelectric Point: 8.0624

>T144576 WP_039344096.1 NZ_CP046608:c2057609-2056713 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA

Download         Length: 897 bp

>T144576 NZ_CP062160:3246251-3246358 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31463.03 Da        Isoelectric Point: 6.7661

>AT144576 WP_039344097.1 NZ_CP046608:c2056716-2055859 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT144576 NZ_CP062160:c3246198-3246137 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FSX8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FSY5

References