Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2086533..2087754 Replicon chromosome
Accession NZ_CP046602
Organism Pseudomonas aeruginosa strain CMC-115

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GO602_RS09870 Protein ID WP_024918215.1
Coordinates 2086533..2087111 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GO602_RS09875 Protein ID WP_024918216.1
Coordinates 2087200..2087754 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO602_RS09855 2081821..2083992 + 2172 WP_024918212.1 type I secretion system permease/ATPase -
GO602_RS09860 2083982..2085169 + 1188 WP_024918213.1 HlyD family efflux transporter periplasmic adaptor subunit -
GO602_RS09865 2085324..2086406 - 1083 WP_058140422.1 FAD-binding oxidoreductase -
GO602_RS09870 2086533..2087111 - 579 WP_024918215.1 HD domain-containing protein Toxin
GO602_RS09875 2087200..2087754 - 555 WP_024918216.1 helix-turn-helix domain-containing protein Antitoxin
GO602_RS09880 2087911..2090106 - 2196 WP_058140421.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
GO602_RS09885 2090111..2090572 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
GO602_RS09890 2090903..2091226 + 324 WP_124181629.1 multidrug efflux SMR transporter -
GO602_RS09895 2091239..2091637 + 399 WP_024918219.1 NADH-quinone oxidoreductase subunit A -
GO602_RS09900 2091634..2092185 - 552 WP_121305624.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.70 Da        Isoelectric Point: 5.0263

>T144569 WP_024918215.1 NZ_CP046602:c2087111-2086533 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLEAQRDA

Download         Length: 579 bp

>T144569 NZ_CP062160:c2084510-2084124 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20458.62 Da        Isoelectric Point: 8.5375

>AT144569 WP_024918216.1 NZ_CP046602:c2087754-2087200 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLLEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGDLLGRSLWPYCSEEILRQETTLEDLGWRELLAPPTLEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT144569 NZ_CP062160:c2084134-2083805 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References