Detailed information of TA system TA144568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1196069..1197327
• Replicon: chromosome
• Accession: NZ_CP046602
• Organism: Pseudomonas aeruginosa strain CMC-115

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: GO602_RS05730
• Protein ID: WP_124181095.1
• Coordinates: 1196572..1197327 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: GO602_RS05725
• Protein ID: WP_003086329.1
• Coordinates: 1196069..1196437 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GO602_RS05700	1191722..1192100	+	379	Protein_1122	OprD family outer membrane porin	-
GO602_RS29700	1192234..1192509	+	276	WP_049942684.1	zinc ribbon domain-containing protein	-
GO602_RS05710	1192512..1192988	-	477	WP_024915076.1	elongation factor GreAB	-
GO602_RS05715	1193065..1194654	+	1590	WP_079752920.1	aldehyde dehydrogenase family protein	-
GO602_RS05720	1194710..1195996	+	1287	WP_124181094.1	FAD-binding oxidoreductase	-
GO602_RS05725	1196069..1196437	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
GO602_RS05730	1196572..1197327	+	756	WP_124181095.1	RES family NAD+ phosphorylase	Toxin
GO602_RS05735	1198099..1199460	+	1362	WP_079752925.1	DNA recombination protein RmuC	-
GO602_RS05740	1199610..1202153	-	2544	WP_124181096.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28371.55 Da
• Isoelectric Point: 7.3881

>T144568 WP_124181095.1 NZ_CP046602:1196572-1197327 [Pseudomonas aeruginosa]
VSEIWRQCKGEWHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLHVPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPVAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPYPA

Nucleotide

• Length: 756 bp

>T144568 NZ_CP062160:c1629444-1629226 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT144568 WP_003086329.1 NZ_CP046602:1196069-1196437 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT144568 NZ_CP062160:c1629844-1629470 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: V6AJU7