Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 145130..145635 Replicon chromosome
Accession NZ_CP046602
Organism Pseudomonas aeruginosa strain CMC-115

Toxin (Protein)


Gene name parE Uniprot ID A0A3S0LZE8
Locus tag GO602_RS00655 Protein ID WP_003156094.1
Coordinates 145130..145411 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag GO602_RS00660 Protein ID WP_003083775.1
Coordinates 145408..145635 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO602_RS00630 140376..141725 + 1350 WP_079752987.1 C4-dicarboxylate transporter DctA -
GO602_RS00635 141774..142460 + 687 WP_058138883.1 FadR family transcriptional regulator -
GO602_RS00640 142562..143296 + 735 WP_024916686.1 GntR family transcriptional regulator -
GO602_RS00645 143500..143886 + 387 WP_187358974.1 aegerolysin family protein -
GO602_RS00650 143921..144829 - 909 WP_024916684.1 LysR family transcriptional regulator -
GO602_RS00655 145130..145411 - 282 WP_003156094.1 type II toxin-antitoxin system toxin ParE Toxin
GO602_RS00660 145408..145635 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
GO602_RS00665 145810..146430 - 621 WP_121129709.1 hypothetical protein -
GO602_RS00670 146531..147031 + 501 WP_024916682.1 LEA type 2 family protein -
GO602_RS00675 147104..147445 + 342 WP_024916681.1 alkylphosphonate utilization protein -
GO602_RS00680 147565..148992 - 1428 WP_003083784.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10433.15 Da        Isoelectric Point: 9.6558

>T144567 WP_003156094.1 NZ_CP046602:c145411-145130 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T144567 NZ_CP062160:1373257-1373655 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT144567 WP_003083775.1 NZ_CP046602:c145635-145408 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT144567 NZ_CP062160:1372961-1373254 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0LZE8

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References