Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 4943063..4943739 Replicon chromosome
Accession NZ_CP046600
Organism Mycobacterium spongiae strain FSD4b-SM

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F6B93_RS19840 Protein ID WP_211696598.1
Coordinates 4943063..4943470 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F6B93_RS19845 Protein ID WP_211696599.1
Coordinates 4943467..4943739 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6B93_RS19820 (F6B93_19790) 4938878..4939498 + 621 WP_211696595.1 hypothetical protein -
F6B93_RS19825 (F6B93_19795) 4939479..4939661 - 183 Protein_3951 cytochrome P450 -
F6B93_RS19830 (F6B93_19800) 4940450..4940656 + 207 WP_211696596.1 transposase -
F6B93_RS19835 (F6B93_19805) 4940871..4942376 + 1506 WP_211696597.1 PE family protein -
F6B93_RS19840 (F6B93_19810) 4943063..4943470 - 408 WP_211696598.1 type II toxin-antitoxin system VapC family toxin Toxin
F6B93_RS19845 (F6B93_19815) 4943467..4943739 - 273 WP_211696599.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F6B93_RS19850 (F6B93_19820) 4943938..4944102 - 165 WP_211696600.1 hypothetical protein -
F6B93_RS19855 (F6B93_19825) 4944112..4944339 + 228 WP_211696601.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14764.67 Da        Isoelectric Point: 4.3824

>T144566 WP_211696598.1 NZ_CP046600:c4943470-4943063 [Mycobacterium spongiae]
MIYMDTSALVKLIVHEAESVHLRRWLADAEDHDHVTSAVGRVELMRTALRSGDTEIVANAQRILGEDLDILAVTDEVIAM
AETIGPDSLRSLDAIHLASATQLGDALTTVVAYDNRLIERCRDLDYPVESPGAGR

Download         Length: 408 bp

>T144566 NZ_CP062160:c1367258-1366998 [Escherichia coli]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9851.45 Da        Isoelectric Point: 12.0401

>AT144566 WP_211696599.1 NZ_CP046600:c4943739-4943467 [Mycobacterium spongiae]
MKVIGVRELRQNASKYLARVAAGEELEVTMRGRLVARLVPVTATERTRDGLIARGAMRPARRRGGLASVDAESLPRRNLS
AVLAEVRADQ

Download         Length: 273 bp

>AT144566 NZ_CP062160:c1367537-1367277 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References