Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4538484..4539067 Replicon chromosome
Accession NZ_CP046600
Organism Mycobacterium spongiae strain FSD4b-SM

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag F6B93_RS18465 Protein ID WP_246540852.1
Coordinates 4538714..4539067 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag F6B93_RS18460 Protein ID WP_211696378.1
Coordinates 4538484..4538681 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6B93_RS18445 (F6B93_18440) 4534152..4536485 - 2334 WP_211696375.1 ATP-dependent DNA ligase -
F6B93_RS18450 (F6B93_18445) 4536508..4537458 + 951 WP_211696376.1 carbohydrate kinase -
F6B93_RS18455 (F6B93_18450) 4537523..4538326 + 804 WP_211696377.1 Ku protein -
F6B93_RS18460 (F6B93_18455) 4538484..4538681 + 198 WP_211696378.1 hypothetical protein Antitoxin
F6B93_RS18465 (F6B93_18460) 4538714..4539067 + 354 WP_246540852.1 Fic family protein Toxin
F6B93_RS18470 (F6B93_18465) 4539122..4539808 - 687 WP_211696380.1 maleylpyruvate isomerase family mycothiol-dependent enzyme -
F6B93_RS18475 (F6B93_18470) 4539943..4540083 - 141 Protein_3688 IS256 family transposase -
F6B93_RS23175 4540515..4541048 + 534 WP_246540854.1 IS110 family transposase -
F6B93_RS23180 4540939..4541355 + 417 WP_246541188.1 IS110 family transposase -
F6B93_RS18485 (F6B93_18480) 4542380..4543981 - 1602 WP_211696381.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4534152..4567873 33721


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-71)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12589.17 Da        Isoelectric Point: 4.2798

>T144564 WP_246540852.1 NZ_CP046600:4538714-4539067 [Mycobacterium spongiae]
VAEYACGFQPLVRDPGLFESSLMRPATVLFGADAYPTVWDKAAALLHSLATTQSLADGNKRTGWAACWLLLGLNGHQVSA
NLDVDAAEEFVLAIAANHLTWEQIAERLPDFAESTTS

Download         Length: 354 bp

>T144564 NZ_CP062160:c1022238-1021897 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7110.00 Da        Isoelectric Point: 11.0634

>AT144564 WP_211696378.1 NZ_CP046600:4538484-4538681 [Mycobacterium spongiae]
VPALNVEFSDEELAKVRSAASDAGTSMRAFARQAILDRAVNREGRVRALGQEIAQRSAELNRRLA

Download         Length: 198 bp

>AT144564 NZ_CP062160:1022233-1022309 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References