Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3030740..3031287 Replicon chromosome
Accession NZ_CP046600
Organism Mycobacterium spongiae strain FSD4b-SM

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag F6B93_RS12360 Protein ID WP_211695362.1
Coordinates 3030740..3031039 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag F6B93_RS12365 Protein ID WP_211695363.1
Coordinates 3031036..3031287 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6B93_RS12335 (F6B93_12330) 3027081..3027287 + 207 WP_211695357.1 DUF3018 family protein -
F6B93_RS12340 (F6B93_12335) 3027284..3027616 + 333 WP_211695358.1 type II toxin-antitoxin system PemK/MazF family toxin -
F6B93_RS12345 (F6B93_12340) 3027809..3029158 - 1350 WP_211695359.1 multidrug effflux MFS transporter -
F6B93_RS12350 (F6B93_12345) 3029229..3029687 + 459 WP_211695360.1 MarR family winged helix-turn-helix transcriptional regulator -
F6B93_RS12355 (F6B93_12350) 3030289..3030528 - 240 WP_211695361.1 hypothetical protein -
F6B93_RS12360 (F6B93_12355) 3030740..3031039 - 300 WP_211695362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6B93_RS12365 (F6B93_12360) 3031036..3031287 - 252 WP_211695363.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
F6B93_RS12370 (F6B93_12365) 3032066..3034198 + 2133 Protein_2476 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11291.57 Da        Isoelectric Point: 5.5104

>T144563 WP_211695362.1 NZ_CP046600:c3031039-3030740 [Mycobacterium spongiae]
VSQYVLSPAAQADLEQIWDFTSERWNDDQAEAYVRVIQRAVELVADNPLIGRSCDEVRAGYRRHTAGSHTLYYRVGAGGD
LVEVVRILHKHMDVDRHLD

Download         Length: 300 bp

>T144563 NZ_CP062160:888790-889140 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9309.33 Da        Isoelectric Point: 6.4713

>AT144563 WP_211695363.1 NZ_CP046600:c3031287-3031036 [Mycobacterium spongiae]
MGRNTSFSLDEHFNAFIEDEVASGRYRSASDVVRAALRLLEERETRLDALREALIAGENSGAPTPFEFDAFVSRKRARAP
HGR

Download         Length: 252 bp

>AT144563 NZ_CP062160:888545-888796 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References