Detailed information of TA system TA144563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3030740..3031287
• Replicon: chromosome
• Accession: NZ_CP046600
• Organism: Mycobacterium spongiae strain FSD4b-SM

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F6B93_RS12360
• Protein ID: WP_211695362.1
• Coordinates: 3030740..3031039 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: F6B93_RS12365
• Protein ID: WP_211695363.1
• Coordinates: 3031036..3031287 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6B93_RS12335 (F6B93_12330)	3027081..3027287	+	207	WP_211695357.1	DUF3018 family protein	-
F6B93_RS12340 (F6B93_12335)	3027284..3027616	+	333	WP_211695358.1	type II toxin-antitoxin system PemK/MazF family toxin	-
F6B93_RS12345 (F6B93_12340)	3027809..3029158	-	1350	WP_211695359.1	multidrug effflux MFS transporter	-
F6B93_RS12350 (F6B93_12345)	3029229..3029687	+	459	WP_211695360.1	MarR family winged helix-turn-helix transcriptional regulator	-
F6B93_RS12355 (F6B93_12350)	3030289..3030528	-	240	WP_211695361.1	hypothetical protein	-
F6B93_RS12360 (F6B93_12355)	3030740..3031039	-	300	WP_211695362.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F6B93_RS12365 (F6B93_12360)	3031036..3031287	-	252	WP_211695363.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
F6B93_RS12370 (F6B93_12365)	3032066..3034198	+	2133	Protein_2476	PE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11291.57 Da
• Isoelectric Point: 5.5104

>T144563 WP_211695362.1 NZ_CP046600:c3031039-3030740 [Mycobacterium spongiae]
VSQYVLSPAAQADLEQIWDFTSERWNDDQAEAYVRVIQRAVELVADNPLIGRSCDEVRAGYRRHTAGSHTLYYRVGAGGD
LVEVVRILHKHMDVDRHLD

Nucleotide

• Length: 300 bp

>T144563 NZ_CP062160:888790-889140 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9309.33 Da
• Isoelectric Point: 6.4713

>AT144563 WP_211695363.1 NZ_CP046600:c3031287-3031036 [Mycobacterium spongiae]
MGRNTSFSLDEHFNAFIEDEVASGRYRSASDVVRAALRLLEERETRLDALREALIAGENSGAPTPFEFDAFVSRKRARAP
HGR

Nucleotide

• Length: 252 bp

>AT144563 NZ_CP062160:888545-888796 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA