Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1367344..1368260 | Replicon | chromosome |
| Accession | NZ_CP046592 | ||
| Organism | Bacillus subtilis strain TR21 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | O34853 |
| Locus tag | GO005_RS07195 | Protein ID | WP_003244695.1 |
| Coordinates | 1367514..1368260 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | G4EXD8 |
| Locus tag | GO005_RS07190 | Protein ID | WP_003232646.1 |
| Coordinates | 1367344..1367514 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GO005_RS07155 | 1364207..1364536 | + | 330 | WP_003232660.1 | phage-like element PBSX protein XkdW | - |
| GO005_RS07160 | 1364533..1364697 | + | 165 | WP_003232658.1 | XkdX family protein | - |
| GO005_RS07165 | 1364741..1365580 | + | 840 | WP_032721388.1 | phage-like element PBSX protein XepA | - |
| GO005_RS07170 | 1365633..1365902 | + | 270 | WP_003232655.1 | hemolysin XhlA family protein | - |
| GO005_RS07175 | 1365915..1366178 | + | 264 | WP_003232653.1 | phage holin | - |
| GO005_RS07180 | 1366191..1367084 | + | 894 | WP_003245230.1 | N-acetylmuramoyl-L-alanine amidase | - |
| GO005_RS07185 | 1367121..1367258 | - | 138 | WP_003232648.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| GO005_RS07190 | 1367344..1367514 | - | 171 | WP_003232646.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| GO005_RS07195 | 1367514..1368260 | - | 747 | WP_003244695.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| GO005_RS07200 | 1368370..1369371 | - | 1002 | WP_003232642.1 | inorganic phosphate transporter | - |
| GO005_RS07205 | 1369384..1370001 | - | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| GO005_RS07210 | 1370277..1371593 | - | 1317 | WP_003244819.1 | serine/threonine exchanger | - |
| GO005_RS07215 | 1371982..1372932 | + | 951 | WP_003245086.1 | ring-cleaving dioxygenase | - |
| GO005_RS07220 | 1373033..1373179 | + | 147 | WP_003244977.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29061.50 Da Isoelectric Point: 4.6191
>T144554 WP_003244695.1 NZ_CP046592:c1368260-1367514 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T144554 NZ_CP062156:3513704-3514132 [Stenotrophomonas sp. CW117]
ATGCGTGCGTTGCTTGACGTGAACGTGCTGATCGCACTGCACGACAGCGACCACGTCCACCATCACCCTGCCTCGGCCTG
GCTGCGCACGCACATCGCGCATGGCTGGGCCAGTTGTCCACTTACCCAGAACGGTTGCCTGCGCATCATGTCCCAGCCCG
GATACGCCAAGCCGCAACCGCTGGCCAGCCTGGTGAGCATGCTGGCGCGTTCCACGTCCACGCGCTTCCATGCGTTCTGG
CCGGACGCCATCAGCGTGCTGGATCGCACGCATTTCCATCATGGCTACATCCACAGTCCGCGACAGTTGACCTATCTGTA
CCTGCTCGCGCTCGCGGTGCACCACGGCGGGCGGCTGGTGACGTTCGACCGGCACATTGCGCTGAGTGCGGTAGCGGGCG
CGCGGCCCGAGCACCTGGTGCAGTTGTGA
ATGCGTGCGTTGCTTGACGTGAACGTGCTGATCGCACTGCACGACAGCGACCACGTCCACCATCACCCTGCCTCGGCCTG
GCTGCGCACGCACATCGCGCATGGCTGGGCCAGTTGTCCACTTACCCAGAACGGTTGCCTGCGCATCATGTCCCAGCCCG
GATACGCCAAGCCGCAACCGCTGGCCAGCCTGGTGAGCATGCTGGCGCGTTCCACGTCCACGCGCTTCCATGCGTTCTGG
CCGGACGCCATCAGCGTGCTGGATCGCACGCATTTCCATCATGGCTACATCCACAGTCCGCGACAGTTGACCTATCTGTA
CCTGCTCGCGCTCGCGGTGCACCACGGCGGGCGGCTGGTGACGTTCGACCGGCACATTGCGCTGAGTGCGGTAGCGGGCG
CGCGGCCCGAGCACCTGGTGCAGTTGTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6654.72 Da Isoelectric Point: 11.0203
>AT144554 WP_003232646.1 NZ_CP046592:c1367514-1367344 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT144554 NZ_CP062156:3513432-3513704 [Stenotrophomonas sp. CW117]
ATCAATCATCAGGGAGAGCCGCATGCGCCCTCCCTCGACATTGCCGACGACGTGCTGTTTGCCGCCAAGGAGCTGGCACG
CCGCGAGAAGAAGCCACTTGGCCAGGTGATCAGCGAGTTGGCGCGGCGGGCGTTCGCCCAGTCCGATGCGCCCTGGGACA
CGACCGGCGTGGCCGAACCCTTGGCCGATTACGGCATTCATCCGCTGCCACCACGCGGCGTGGTGGTCAGCAATGAACTC
ATCGATCGCCTGCGCGACGAAGAGGGCATCTGA
ATCAATCATCAGGGAGAGCCGCATGCGCCCTCCCTCGACATTGCCGACGACGTGCTGTTTGCCGCCAAGGAGCTGGCACG
CCGCGAGAAGAAGCCACTTGGCCAGGTGATCAGCGAGTTGGCGCGGCGGGCGTTCGCCCAGTCCGATGCGCCCTGGGACA
CGACCGGCGTGGCCGAACCCTTGGCCGATTACGGCATTCATCCGCTGCCACCACGCGGCGTGGTGGTCAGCAATGAACTC
ATCGATCGCCTGCGCGACGAAGAGGGCATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|