Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 572853..573489 | Replicon | chromosome |
Accession | NZ_CP046592 | ||
Organism | Bacillus subtilis strain TR21 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G4NU33 |
Locus tag | GO005_RS02990 | Protein ID | WP_003156187.1 |
Coordinates | 573139..573489 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G4NU32 |
Locus tag | GO005_RS02985 | Protein ID | WP_003225183.1 |
Coordinates | 572853..573134 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GO005_RS02965 | 569212..569811 | - | 600 | WP_032722928.1 | rhomboid family intramembrane serine protease | - |
GO005_RS02970 | 569906..570271 | + | 366 | WP_015252768.1 | holo-ACP synthase | - |
GO005_RS02975 | 570437..571453 | + | 1017 | WP_003234282.1 | outer membrane lipoprotein carrier protein LolA | - |
GO005_RS02980 | 571568..572737 | + | 1170 | WP_032722929.1 | alanine racemase | - |
GO005_RS02985 | 572853..573134 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
GO005_RS02990 | 573139..573489 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
GO005_RS02995 | 573604..574428 | + | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
GO005_RS03000 | 574433..574798 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
GO005_RS03005 | 574802..575203 | + | 402 | WP_003246640.1 | serine/threonine-protein kinase RsbT | - |
GO005_RS03010 | 575215..576222 | + | 1008 | WP_003234295.1 | phosphoserine phosphatase RsbU | - |
GO005_RS03015 | 576284..576613 | + | 330 | WP_003234298.1 | anti-sigma factor antagonist RsbV | - |
GO005_RS03020 | 576610..577092 | + | 483 | WP_003234299.1 | anti-sigma B factor RsbW | - |
GO005_RS03025 | 577058..577846 | + | 789 | WP_029727187.1 | RNA polymerase sigma factor SigB | - |
GO005_RS03030 | 577846..578445 | + | 600 | WP_003234303.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T144553 WP_003156187.1 NZ_CP046592:573139-573489 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T144553 NZ_CP062152:c812650-811325 [Vibrio parahaemolyticus]
ATGGTGAAGCAATTACGCGTGTTAATGAATGGTGAGTCAGTAGGGGTGTTCACTAAAGAACCTAGTGGTGCTCATAGCTT
TCAATACGGAGAAGACTGGTTAAACTCTAGTAAATCTCGCCCGATATCATTATCAATCCCCCTTCGCCGTGAGCCGTACA
GGGGTGATATAGTGATTAACTTTTTCGACAACCTGCTTCCAGATAACCCTCAGGTTCGAGACCGAATCGTTGCTCGATAC
GGTGCCAAAACAAAACAACCATTCGATCTTTTGGAAAAGATAGGGCGCGATAGCGTTGGGGCAATCACTCTTATTCCTGA
AGGCGAGCCGATACCAGAATTTAAGGGAATAAGAGCTACTGAGCTTTCCCTTATAAAGCTTGAACAAGTTCTTAATTCCT
ATGCAGACAATATCCCTTTAGGAATGGTTGATGGAAATGATGATTTCAGGATCTCCATTGCTGGCGCTCAAGAGAAAACT
GCCTTGTTGAAGTTAGATGGGCGTTGGTATATACCGCAAGGTGCAACTCCAACCACACACATTATAAAACTACCTATTGG
AGAAATACGGACGCAGGACAGCGTTTTAGACCTAACAACCAGCGTTGATAATGAACTCGTGTGTATGAGACTTTCTGAAG
CGTTTGGACTTCCTACAGCCTCTTGTGACGTTATTAGGGCTGGTGGAGTAAGGGCGCTTGCCGTTGAGCGTTTCGATAGA
CGATTCTCACAACTTAAGGATTGGATTGTACGCTTGCCTCAAGAAGACTTTTGCCAGGTGTCTGGTATGCCATCAGCAAG
CAAGTATGAATCAGATGGTGGTATCGGTATTGAAGGAATTATGGATCACCTTCTTGGCTCAGAGGTTCCTCAGGAAGACA
GAAGAACCTTTATGCGTTCTCAAGTTCTGTTCTATTTACTTGCTGCAATAGATGGTCACTCAAAAAACTTTTCGTTATTC
ATAGAGCCTCATGGTAAGTACCGATTAACGCCTTTGTACGACATTATGTCAGCCTACCCTCTTATGGGTGGTAGAGGGCT
TCATGAAAGAAAAATCAAGCTGGCAATGGGGCTTAAGGCAAGTAGCGGATACAAGCGTAAGTGGCATCAGATACAGCCTA
GACATTTTATCGGTACAGCGAGGCTGGTGAAGTATTCATCGGACTCAATGAGAGATATTCTGGATGAGTTTATAACTGAT
TGTGGACAGGTTATCGATCTGGTTGGGAACGATTTGCCAGATGATATCAATGAGAATGTTCGGGATAAAATTTTTGAGGG
ATTAACAAAATCAGTGAAAAAACTGAGTCTTGGTCTGAATGAGTAG
ATGGTGAAGCAATTACGCGTGTTAATGAATGGTGAGTCAGTAGGGGTGTTCACTAAAGAACCTAGTGGTGCTCATAGCTT
TCAATACGGAGAAGACTGGTTAAACTCTAGTAAATCTCGCCCGATATCATTATCAATCCCCCTTCGCCGTGAGCCGTACA
GGGGTGATATAGTGATTAACTTTTTCGACAACCTGCTTCCAGATAACCCTCAGGTTCGAGACCGAATCGTTGCTCGATAC
GGTGCCAAAACAAAACAACCATTCGATCTTTTGGAAAAGATAGGGCGCGATAGCGTTGGGGCAATCACTCTTATTCCTGA
AGGCGAGCCGATACCAGAATTTAAGGGAATAAGAGCTACTGAGCTTTCCCTTATAAAGCTTGAACAAGTTCTTAATTCCT
ATGCAGACAATATCCCTTTAGGAATGGTTGATGGAAATGATGATTTCAGGATCTCCATTGCTGGCGCTCAAGAGAAAACT
GCCTTGTTGAAGTTAGATGGGCGTTGGTATATACCGCAAGGTGCAACTCCAACCACACACATTATAAAACTACCTATTGG
AGAAATACGGACGCAGGACAGCGTTTTAGACCTAACAACCAGCGTTGATAATGAACTCGTGTGTATGAGACTTTCTGAAG
CGTTTGGACTTCCTACAGCCTCTTGTGACGTTATTAGGGCTGGTGGAGTAAGGGCGCTTGCCGTTGAGCGTTTCGATAGA
CGATTCTCACAACTTAAGGATTGGATTGTACGCTTGCCTCAAGAAGACTTTTGCCAGGTGTCTGGTATGCCATCAGCAAG
CAAGTATGAATCAGATGGTGGTATCGGTATTGAAGGAATTATGGATCACCTTCTTGGCTCAGAGGTTCCTCAGGAAGACA
GAAGAACCTTTATGCGTTCTCAAGTTCTGTTCTATTTACTTGCTGCAATAGATGGTCACTCAAAAAACTTTTCGTTATTC
ATAGAGCCTCATGGTAAGTACCGATTAACGCCTTTGTACGACATTATGTCAGCCTACCCTCTTATGGGTGGTAGAGGGCT
TCATGAAAGAAAAATCAAGCTGGCAATGGGGCTTAAGGCAAGTAGCGGATACAAGCGTAAGTGGCATCAGATACAGCCTA
GACATTTTATCGGTACAGCGAGGCTGGTGAAGTATTCATCGGACTCAATGAGAGATATTCTGGATGAGTTTATAACTGAT
TGTGGACAGGTTATCGATCTGGTTGGGAACGATTTGCCAGATGATATCAATGAGAATGTTCGGGATAAAATTTTTGAGGG
ATTAACAAAATCAGTGAAAAAACTGAGTCTTGGTCTGAATGAGTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT144553 WP_003225183.1 NZ_CP046592:572853-573134 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT144553 NZ_CP062152:c812901-812644 [Vibrio parahaemolyticus]
ATGTTGATAACATCATCCAGGCAGTTAGCAATACATCTTCGTGATGAAAGAAAAAGCAGGAAACTATCTCAAGCAAAAGT
TGCCGATCCAGTAGGGATAAAACAAGACACGGTTTCTAAGTTTGAGGTTAATCCTGAAACCACCAGCATTCAGACGCTAT
TTCGAATCTTATCATCGTTAAATTTGGAAATGCATATTGTGCCGAAAGGTCAAAGCATCGAACCAAAAACTGATAATGAG
AGTGATGAGACATGGTGA
ATGTTGATAACATCATCCAGGCAGTTAGCAATACATCTTCGTGATGAAAGAAAAAGCAGGAAACTATCTCAAGCAAAAGT
TGCCGATCCAGTAGGGATAAAACAAGACACGGTTTCTAAGTTTGAGGTTAATCCTGAAACCACCAGCATTCAGACGCTAT
TTCGAATCTTATCATCGTTAAATTTGGAAATGCATATTGTGCCGAAAGGTCAAAGCATCGAACCAAAAACTGATAATGAG
AGTGATGAGACATGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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