Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1556041..1556532 Replicon chromosome
Accession NZ_CP046590
Organism Macrococcus canis strain LI021

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GOY09_RS07970 Protein ID WP_086043355.1
Coordinates 1556182..1556532 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GOY09_RS07965 Protein ID WP_101495293.1
Coordinates 1556041..1556181 (+) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOY09_RS07940 (GOY09_07920) 1552031..1552507 + 477 WP_138072455.1 PH domain-containing protein -
GOY09_RS07945 (GOY09_07925) 1552497..1554008 + 1512 WP_211552557.1 PH domain-containing protein -
GOY09_RS07950 (GOY09_07930) 1553992..1554513 + 522 WP_211552563.1 PH domain-containing protein -
GOY09_RS07955 (GOY09_07935) 1554455..1554811 + 357 WP_211552565.1 holo-ACP synthase -
GOY09_RS07960 (GOY09_07940) 1554837..1555979 + 1143 WP_211552581.1 alanine racemase -
GOY09_RS07965 (GOY09_07945) 1556041..1556181 + 141 WP_101495293.1 antitoxin MazE Antitoxin
GOY09_RS07970 (GOY09_07950) 1556182..1556532 + 351 WP_086043355.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GOY09_RS07975 (GOY09_07955) 1556581..1557588 + 1008 WP_210152200.1 PP2C family protein-serine/threonine phosphatase -
GOY09_RS07980 (GOY09_07960) 1557669..1557992 + 324 WP_086043353.1 anti-sigma factor antagonist -
GOY09_RS07985 (GOY09_07965) 1557997..1558440 + 444 WP_086043352.1 anti-sigma B factor RsbW -
GOY09_RS07990 (GOY09_07970) 1558445..1559212 + 768 WP_211552586.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12705.88 Da        Isoelectric Point: 9.9423

>T144550 WP_086043355.1 NZ_CP046590:1556182-1556532 [Macrococcus canis]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTTHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDVALLISLGLSIDSE

Download         Length: 351 bp

>T144550 NZ_CP062147:3252809-3253102 [Komagataeibacter hansenii]
ATGAAAGAGTATTGTCTTGAATTCGACGACAGAGCGCTCAGAGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAGCTGATCTGGAACCCTCACTCTCCAGGAAACGAACTGCATCGCGACCTATCAGGGTTTTATA
AGATCAAGCTTCTGAAAGATGGTTACCGCCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTAATTGCCGTT
GGCCGGAGAGCCGATAATGAGATTTATGAACTGGCTTCGAAGCGAACAGAGTGA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5319.89 Da        Isoelectric Point: 3.8301

>AT144550 WP_101495293.1 NZ_CP046590:1556041-1556181 [Macrococcus canis]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTYTLDGE

Download         Length: 141 bp

>AT144550 NZ_CP062147:3252552-3252812 [Komagataeibacter hansenii]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References