144544

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2509129..2510885 Replicon chromosome
Accession NZ_CP046583
Organism Burkholderia pseudomallei strain B03

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GN245_RS11330 Protein ID WP_038760221.1
Coordinates 2509980..2510885 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GN245_RS11325 Protein ID WP_038760219.1
Coordinates 2509129..2509983 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN245_RS11305 2504345..2505835 - 1491 WP_038760215.1 aldehyde dehydrogenase -
GN245_RS11310 2505861..2506676 - 816 WP_004195445.1 aspartate dehydrogenase -
GN245_RS11315 2506669..2508342 - 1674 WP_038760217.1 thiamine pyrophosphate-binding protein -
GN245_RS11320 2508335..2509132 - 798 WP_004524003.1 SDR family oxidoreductase -
GN245_RS11325 2509129..2509983 - 855 WP_038760219.1 IclR family transcriptional regulator Antitoxin
GN245_RS11330 2509980..2510885 - 906 WP_038760221.1 alpha/beta fold hydrolase Toxin
GN245_RS11335 2510902..2511429 - 528 WP_004524001.1 cupin domain-containing protein -
GN245_RS11340 2511468..2512238 - 771 WP_004524000.1 SDR family oxidoreductase -
GN245_RS11345 2512235..2513302 - 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
GN245_RS11350 2513337..2513648 - 312 WP_004184841.1 hypothetical protein -
GN245_RS11355 2513650..2513967 - 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
GN245_RS11360 2514402..2515490 + 1089 WP_009976194.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30582.77 Da        Isoelectric Point: 8.4944

>T144544 WP_038760221.1 NZ_CP046583:c2510885-2509980 [Burkholderia pseudomallei]
MSTISTTTTEAGAALFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGPRGTP

Download         Length: 906 bp

>T144544 NZ_CP062146:c3402824-3401886 [Proteus mirabilis]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCTTTGCTCATAAGAATGCTGCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAATTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGGCAGTTCAAGAGTCTGTTGAATACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGGTTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACATTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCGCTGAATGAGAAATTTCAGGCAGAAT
TTGATGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCTTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATTATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATAAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31200.61 Da        Isoelectric Point: 6.8932

>AT144544 WP_038760219.1 NZ_CP046583:c2509983-2509129 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRFGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALIAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT144544 NZ_CP062146:c3403608-3402817 [Proteus mirabilis]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References