Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 4405132..4405768 Replicon chromosome
Accession NZ_CP046582
Organism Erwinia sp. E602

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag GKQ23_RS21815 Protein ID WP_212409422.1
Coordinates 4405132..4405455 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag GKQ23_RS21820 Protein ID WP_212409423.1
Coordinates 4405436..4405768 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ23_RS21800 (GKQ23_21725) 4400644..4402293 - 1650 WP_056235171.1 Na+/H+ antiporter -
GKQ23_RS21805 (GKQ23_21730) 4402505..4403851 - 1347 WP_056235168.1 NCS2 family permease -
GKQ23_RS21810 (GKQ23_21735) 4404199..4404861 - 663 WP_056235165.1 glutathione S-transferase -
GKQ23_RS21815 (GKQ23_21740) 4405132..4405455 + 324 WP_212409422.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GKQ23_RS21820 (GKQ23_21745) 4405436..4405768 + 333 WP_212409423.1 helix-turn-helix transcriptional regulator Antitoxin
GKQ23_RS21825 (GKQ23_21750) 4405806..4406273 - 468 WP_056235155.1 redox-sensitive transcriptional activator SoxR -
GKQ23_RS21830 (GKQ23_21755) 4406397..4406822 + 426 WP_212409424.1 superoxide response transcriptional regulator SoxS -
GKQ23_RS21835 (GKQ23_21760) 4406819..4407673 - 855 WP_212409425.1 GGDEF domain-containing protein -
GKQ23_RS21840 (GKQ23_21765) 4407697..4408113 - 417 WP_212409426.1 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD -
GKQ23_RS21845 (GKQ23_21770) 4408840..4409121 + 282 WP_056235137.1 YjcB family protein -
GKQ23_RS21850 (GKQ23_21775) 4409589..4409984 + 396 WP_056235135.1 transposase -
GKQ23_RS21855 (GKQ23_21780) 4410121..4410564 - 444 WP_101506133.1 DUF3828 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-93)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12032.86 Da        Isoelectric Point: 8.5446

>T144542 WP_212409422.1 NZ_CP046582:4405132-4405455 [Erwinia sp. E602]
MSLPTAIQRFFGFALDFAQRGEKHDSVKVLKGFGSAGVLEVVEDDIGGTYRAVYTVKFSEAVFVLHAFQKKSKQGIMTPK
EDMEIVRIRLKVAETIAQELRNEKDSH

Download         Length: 324 bp

>T144542 NZ_CP062146:c1542215-1542030 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11951.99 Da        Isoelectric Point: 9.3113

>AT144542 WP_212409423.1 NZ_CP046582:4405436-4405768 [Erwinia sp. E602]
MKKTVIDGITVEQGSDNVFADLGLRDAEKHKIKSGLAIEIIKSIRRLGLTQAAAGERMGISQAKVSNLLRGDFTHLSERK
LMECLNRLGCDIEIVITPSSSPIGHLKLAI

Download         Length: 333 bp

>AT144542 NZ_CP062146:c1541983-1541570 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References