Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3617471..3618111 Replicon chromosome
Accession NZ_CP046582
Organism Erwinia sp. E602

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GKQ23_RS18120 Protein ID WP_056240251.1
Coordinates 3617471..3617653 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GKQ23_RS18125 Protein ID WP_212409076.1
Coordinates 3617674..3618111 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ23_RS18085 (GKQ23_18040) 3612477..3613553 + 1077 WP_212409070.1 urea ABC transporter permease subunit UrtC -
GKQ23_RS18090 (GKQ23_18045) 3613546..3614337 + 792 WP_212409071.1 urea ABC transporter ATP-binding protein UrtD -
GKQ23_RS18095 (GKQ23_18050) 3614339..3615037 + 699 WP_212409072.1 urea ABC transporter ATP-binding subunit UrtE -
GKQ23_RS18100 (GKQ23_18055) 3615204..3615704 + 501 WP_212409073.1 hypothetical protein -
GKQ23_RS18105 (GKQ23_18060) 3615731..3616237 - 507 WP_212409074.1 DUF1640 domain-containing protein -
GKQ23_RS18110 (GKQ23_18065) 3616292..3616636 - 345 WP_249168425.1 hypothetical protein -
GKQ23_RS18115 (GKQ23_18070) 3616816..3617301 + 486 WP_212409075.1 hypothetical protein -
GKQ23_RS18120 (GKQ23_18075) 3617471..3617653 + 183 WP_056240251.1 type II toxin-antitoxin system HicA family toxin Toxin
GKQ23_RS18125 (GKQ23_18080) 3617674..3618111 + 438 WP_212409076.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GKQ23_RS18130 (GKQ23_18085) 3618163..3619185 - 1023 WP_212409077.1 AraC family transcriptional regulator -
GKQ23_RS18135 (GKQ23_18090) 3619248..3620450 + 1203 WP_212409078.1 MFS transporter -
GKQ23_RS18140 (GKQ23_18095) 3620691..3621395 - 705 WP_249168426.1 DUF3142 domain-containing protein -
GKQ23_RS24095 3621430..3621552 - 123 WP_256442806.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6565.75 Da        Isoelectric Point: 10.9071

>T144540 WP_056240251.1 NZ_CP046582:3617471-3617653 [Erwinia sp. E602]
MKSSDLIRELALAGCEIKRNTGGSHQIWWSPLSGKTFPVPHPKKDLPIGTVRSIKKLAGI

Download         Length: 183 bp

>T144540 NZ_CP062146:c101372-100029 [Proteus mirabilis]
ATGAAAGCTCAAATACTATCTGTTGCTATGAATGGTGATTTGGTTGGTAAACTAACCAAAAATACTGATGGTGGGATGTC
ATTTCAATACGCAGAAGAATGGTTGGCTGAACCAGGAGCGCGGGCAATCTCATTATCACTTCCTTTGCAAAAGGGGCGCA
TAATCGGTAGCGCAGTTTACAATTTCTTCAGCAACCTTTTACCTGATTCTGAGGCAATTATTGATAGAATGCAGATTCGT
TTTAAGGTAAAAACAAACCATCCTTTTGATCTGCTAGCCGCTGTAGGTCGTGACTGTGTTGGCGCAATCCAATTATATTC
TCCTGATACTGAAATTCCATCGGTGATGGAAACCCATGCTGAACCTTTAAATGAAAATCAAATCGAAGAGCTTTTAGACG
GTTATCAAACCGCCCCCCTTGGAATGTCCGAGGATGTAGACTTTCGGATCTCCCTTGCAGGGGCTCAAGAGAAAACAGCA
TTACTTTGGTATCAAGACTGTTGGCAGCGACCACAAGGCAGTACCCCGACAAGTCATATTTTCAAATTACCCATAGGTCT
GATTGAACACCATAATATTGATCTGCGCGAAAGCTGTGAAAACGAATGGCTATGCTTGTGTATAGCAAGAGAATTTGGAT
TTCCAGTCACCAACGCTGAATTGGCAATATTCGGTCAGAAAAAGGTACTGATCGTAGAGCGTTTTGACCGAAAATGGTCC
TCATCTGGGAACTGGCTGTTGCGCCTTCCCCAAGAGGATTGCTGTCAGGCTTTGAGTGTTGCCCCTGCATTAAAATATGA
ATCTGATGGTGGTCCAGGCATTGAATCTATCATGACGTTGCTTTTGGGCTCACAAAAAGCCATCGACGATAGAGAAATGT
TTTTTAAATCACAAATTCTGTTCTGGATGCTGGCCGCTATAGATGGGCATGGGAAAAACTTTTCCATCTTCATTGAATCT
GGGACATCTTTTCGTTTAACGCCCTTGTATGATGTTATGTCTGCTTTCCCAATTTTTGAAGCACGAGGAATTGAGATAAA
AAAGGCCAAAATGGCTATGGCATTACAAGGAAAAAACAGACAATACAATTTTTCCATGATACAACCTCGTCATTTTATCT
CTACCGCTACAAAGGTCGGGTTTCCAACAAAAACCGCAATGGAGCTAATGATTGATATGGCCGAAAAGACTGATGCAGTT
ATAGCTACCGTATCATCTCAACTGCCTGCGGACTTTCCTGAGCATATCAGTAACGCCATATTTAGTGGGTTATCAATACA
AGCCGATAAGATTAAAAGATGGTCTTCAGGAACGAGCCCACAAAATATGATGGTTTCGAATTGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16173.10 Da        Isoelectric Point: 4.1259

>AT144540 WP_212409076.1 NZ_CP046582:3617674-3618111 [Erwinia sp. E602]
MLFSIGVETPENSDSAWGIIVPALSAYDYGCVSAADTHEEIAAMAREAILLIVEEMLLSGNYSVEQIEDGGVVRYAQDEE
YADYDRWFVIEVDLSAFSGKPQRINISLPDTLLGRIDRRVSDQPGVYRDRSHFLATAARRELLAQ

Download         Length: 438 bp

>AT144540 NZ_CP062146:c101627-101376 [Proteus mirabilis]
ATGAAAATTACAACGCCATCAATGTTAGCCGCTGCAATACATGACTTGCGCAAACAAAGTAAATTAACCCAAGCTCAAAC
GGCTGAACAAGTCGGTCTCAGGCAAGCAACTGTCTCTGAATTTGAGAACAACCCAGAATCAACAAAACTCGAAACGCTTT
TTAAAATCCTTGCCTCTTTGGAACTGGAACTACATGTAGTGAAGCGAGGAAAAAACCTGAGTGAGGGTAAGGTTTGGAAT
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References