Detailed information of TA system TA144531

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2546308..2546843
• Replicon: chromosome
• Accession: NZ_CP046582
• Organism: Erwinia sp. E602

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GKQ23_RS13005
• Protein ID: WP_212408441.1
• Coordinates: 2546556..2546843 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GKQ23_RS13000
• Protein ID: WP_212411791.1
• Coordinates: 2546308..2546559 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ23_RS12975 (GKQ23_12910)	2541508..2541876	-	369	WP_212408436.1	helix-turn-helix domain-containing protein	-
GKQ23_RS12980 (GKQ23_12915)	2541880..2542182	-	303	WP_212408437.1	type II toxin-antitoxin system HigB family toxin	-
GKQ23_RS12985 (GKQ23_12920)	2542274..2543074	-	801	WP_212408438.1	glucosamine-6-phosphate deaminase	-
GKQ23_RS12990 (GKQ23_12925)	2543259..2544275	-	1017	WP_212408439.1	Mal regulon transcriptional regulator MalI	-
GKQ23_RS12995 (GKQ23_12930)	2544353..2545852	-	1500	WP_212408440.1	PTS transporter subunit EIIC	-
GKQ23_RS13000 (GKQ23_12935)	2546308..2546559	+	252	WP_212411791.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GKQ23_RS13005 (GKQ23_12940)	2546556..2546843	+	288	WP_212408441.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GKQ23_RS13010 (GKQ23_12945)	2547150..2547578	-	429	WP_212408442.1	hypothetical protein	-
GKQ23_RS13015 (GKQ23_12950)	2547575..2547967	-	393	WP_212408443.1	hypothetical protein	-
GKQ23_RS13020 (GKQ23_12955)	2548335..2548472	+	138	WP_212411972.1	hypothetical protein	-
GKQ23_RS13025 (GKQ23_12960)	2548726..2549796	-	1071	WP_212408444.1	GTP pyrophosphokinase	-
GKQ23_RS13030 (GKQ23_12965)	2550241..2550534	-	294	WP_212408445.1	hypothetical protein	-
GKQ23_RS13035 (GKQ23_12970)	2550528..2550839	-	312	WP_212408446.1	hypothetical protein	-
GKQ23_RS23900	2550839..2551387	-	549	WP_249168403.1	hypothetical protein	-
GKQ23_RS13045 (GKQ23_12980)	2551384..2551812	-	429	WP_212408447.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2541880..2582213	40333

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11073.02 Da
• Isoelectric Point: 10.5819

>T144531 WP_212408441.1 NZ_CP046582:2546556-2546843 [Erwinia sp. E602]
VTYRVKFREDALKEWHKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDGELVIAVVAVGK
RERSEVYNLASERLR

Nucleotide

• Length: 288 bp

>T144531 NZ_CP062125:c39177-38836 [Listeria monocytogenes]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9081.33 Da
• Isoelectric Point: 3.9507

>AT144531 WP_212411791.1 NZ_CP046582:2546308-2546559 [Erwinia sp. E602]
MPAIILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKLLDALDDQELVKQVAERSNQPLIDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT144531 NZ_CP062125:c39413-39171 [Listeria monocytogenes]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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