Detailed information of TA system TA144526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 795713..796239
• Replicon: chromosome
• Accession: NZ_CP046582
• Organism: Erwinia sp. E602

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: GKQ23_RS05020
• Protein ID: WP_212409927.1
• Coordinates: 795713..796018 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: GKQ23_RS05025
• Protein ID: WP_212409928.1
• Coordinates: 796021..796239 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKQ23_RS05005 (GKQ23_04990)	791206..792609	+	1404	WP_101505364.1	cytosine permease	-
GKQ23_RS05010 (GKQ23_04995)	792714..793622	-	909	WP_212409925.1	LysR family transcriptional regulator	-
GKQ23_RS05015 (GKQ23_05000)	794042..795529	+	1488	WP_212409926.1	PTS N-acetylmuramic acid transporter subunit IIBC	-
GKQ23_RS05020 (GKQ23_05005)	795713..796018	-	306	WP_212409927.1	type II toxin-antitoxin system toxin CcdB	Toxin
GKQ23_RS05025 (GKQ23_05010)	796021..796239	-	219	WP_212409928.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
GKQ23_RS05035 (GKQ23_05020)	796836..798068	+	1233	WP_212409929.1	SpoIIE family protein phosphatase	-
GKQ23_RS05040 (GKQ23_05025)	798095..798652	+	558	WP_056231727.1	SiaB family protein kinase	-
GKQ23_RS05045 (GKQ23_05030)	798671..799063	+	393	WP_212409930.1	DUF1987 domain-containing protein	-
GKQ23_RS05050 (GKQ23_05035)	799060..799785	+	726	WP_212409931.1	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11644.50 Da
• Isoelectric Point: 5.5881

>T144526 WP_212409927.1 NZ_CP046582:c796018-795713 [Erwinia sp. E602]
MQFILYEYRRISHYKMFVDVQSDIVETPKRRMVIPLTEAHHLSEKVNKTLFPLIPVNGENYRLMTTELSSVPVDVIGGAI
TDLGDYADDIKNAINLMFWGI

Nucleotide

• Length: 306 bp

>T144526 NZ_CP062122:c4366033-4365758 [Pseudomonas sp. ADPe]
GTGCTATCGATCATCTGGCGCAGGAGTGCCAGTGATGACCTCGCGACCATTCTCGCCTATATAGCCAACGAGGATCCCCA
AGCAGCAAGGCGCCTCAAGGAACGCGTGGAGTCTGCCGTGCTGCCGTTGGCCCAGCATCCCTACCTTTACCGTCATGGAC
GAGTACCCGGCACACGAGAAGTCGTGATCCACCCCAACTACATCCTGGTTTACCGGATCGACGCTGAATGCATCGAAGTA
GTCAGCGTCCTGCATTCGCGCCAGGAATATCCCTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8266.24 Da
• Isoelectric Point: 7.3199

>AT144526 WP_212409928.1 NZ_CP046582:c796239-796021 [Erwinia sp. E602]
MKHRVSVTVDKDHYQVLSAAGINISGLVNEAIGREARRIKAEEWKKENREGMEEVARFIAHNGSFADENRNW

Nucleotide

• Length: 219 bp

>AT144526 NZ_CP062122:c4366227-4366033 [Pseudomonas sp. ADPe]
ATGAGCGCCCGACTTTCCCCCATAGTCTCCGAGTTCGAAACCCCGGAGCAGGCAGCCAGCCATGATCGCTGGTTCCGCCA
AAAGGTGCAGAAGTCCCTTACAGACAACCAACCAGGGCGTCCCCATGACGAGGTAATGGTCGACATGGACGCCATCATTG
CCCAGGCCGAAGCCCGGCGCCAGGGCAACGACTAG