Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 171105..171655 Replicon chromosome
Accession NZ_CP046582
Organism Erwinia sp. E602

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GKQ23_RS02155 Protein ID WP_212409653.1
Coordinates 171347..171655 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GKQ23_RS02150 Protein ID WP_212409652.1
Coordinates 171105..171344 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ23_RS02115 (GKQ23_02110) 166413..166745 + 333 WP_056240607.1 helix-turn-helix domain-containing protein -
GKQ23_RS02120 (GKQ23_02115) 166760..166990 + 231 WP_212409648.1 hypothetical protein -
GKQ23_RS02125 (GKQ23_02120) 167083..167349 + 267 WP_212409649.1 type II toxin-antitoxin system ParD family antitoxin -
GKQ23_RS02130 (GKQ23_02125) 167327..167632 + 306 WP_212409650.1 type II toxin-antitoxin system RelE/ParE family toxin -
GKQ23_RS02135 (GKQ23_02130) 167763..168269 + 507 WP_056240600.1 TIGR00645 family protein -
GKQ23_RS02140 (GKQ23_02135) 168895..169818 + 924 WP_056240596.1 substrate-binding domain-containing protein -
GKQ23_RS02145 (GKQ23_02140) 170083..170976 + 894 WP_212409651.1 alpha/beta hydrolase -
GKQ23_RS02150 (GKQ23_02145) 171105..171344 + 240 WP_212409652.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
GKQ23_RS02155 (GKQ23_02150) 171347..171655 + 309 WP_212409653.1 CcdB family protein Toxin
GKQ23_RS02160 (GKQ23_02155) 171710..173179 - 1470 WP_212409654.1 aspartate aminotransferase family protein -
GKQ23_RS02165 (GKQ23_02160) 173194..174576 - 1383 WP_056241170.1 diaminobutyrate--2-oxoglutarate transaminase -
GKQ23_RS02170 (GKQ23_02165) 175516..176337 - 822 WP_212409655.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11563.44 Da        Isoelectric Point: 8.0307

>T144523 WP_212409653.1 NZ_CP046582:171347-171655 [Erwinia sp. E602]
MQYRVYRNQSGSQSHPWLLDVQSDIIGQLNTRLVIPLFPRDRFKGTQPVRLCPVVKIEGKEYLVMTHQMASVLSSMLGEE
ITSLAAQRDEIKAAIDFLLAGF

Download         Length: 309 bp

>T144523 NZ_CP062122:2814277-2814558 [Pseudomonas sp. ADPe]
ATGAGCCTGCAGTGGACGCACAAGGCAGCCGCCGACCTGGACGGCCTGTACGACCACTACGTGGTGCTGATCGGCCCGGA
GAAGGCGCTCAAGGCCATCCAGGACGTGGTCGGCCAGGTAAAGGCGCTGGCCGACCTCAGCCTGAGCAGCGTCGGCCGGC
CCAGCGAGGTGCCCGGCGTGCGCGAATTGCCGCTGGAACGCTGGCCCTACCAGGCCGCCTACCGGGTGAAAGGCCGCGAT
GTACAAATTTTGCGCATCGATTCTGTGGATAACCCGGGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8796.83 Da        Isoelectric Point: 6.2833

>AT144523 WP_212409652.1 NZ_CP046582:171105-171344 [Erwinia sp. E602]
MSTSSATQKKTVSVTLDPALYDEARRAGINLSATLAIALLSELRATAARRWQQENQQGLDELNRITEENGLLSDRYRAF

Download         Length: 240 bp

>AT144523 NZ_CP062122:2814053-2814280 [Pseudomonas sp. ADPe]
TTGACCACCGTAATCTCCTTCCGCGCCGATGACGCCCTGGCCAAGGCCCTGGACCAGCTGGCCCGGGCCACCCACCGGGA
CCGCCCCTACCACCTGCGCCAGGCCCTGGCGCAGTACCTGGAGCGCCAGAGCTGGCACGTGGCGGCCATCGACGAAGGCC
TGGCCGACGCCAACGCCGGGCACCTGCTGCCGCACGCGGAGATAGAAGCCAAGTGGGGGCCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References