Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4336029..4336570 Replicon chromosome
Accession NZ_CP046572
Organism Rhodococcus sp. WAY2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GFS60_RS19900 Protein ID WP_159923892.1
Coordinates 4336271..4336570 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GFS60_RS19895 Protein ID WP_159923890.1
Coordinates 4336029..4336271 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFS60_RS19875 4331142..4332542 - 1401 WP_159923885.1 3-isopropylmalate dehydratase large subunit -
GFS60_RS19880 4332603..4333874 - 1272 WP_159927365.1 2-hydroxycarboxylate transporter family protein -
GFS60_RS19885 4334267..4334632 + 366 WP_159923886.1 metalloregulator ArsR/SmtB family transcription factor -
GFS60_RS19890 4334641..4335837 + 1197 WP_201453404.1 CoA transferase -
GFS60_RS19895 4336029..4336271 + 243 WP_159923890.1 antitoxin Antitoxin
GFS60_RS19900 4336271..4336570 + 300 WP_159923892.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GFS60_RS19905 4336926..4337089 - 164 Protein_3935 IS110 family transposase -
GFS60_RS19910 4337116..4337511 - 396 WP_159923894.1 DUF5313 family protein -
GFS60_RS19915 4337508..4337978 - 471 WP_159923896.1 MarR family transcriptional regulator -
GFS60_RS19920 4338090..4338515 - 426 WP_109335379.1 hypothetical protein -
GFS60_RS19925 4338875..4339939 - 1065 WP_159923898.1 methyltransferase domain-containing protein -
GFS60_RS19930 4339977..4340789 - 813 WP_159923900.1 energy-coupling factor ABC transporter ATP-binding protein -
GFS60_RS19935 4340786..4341550 - 765 WP_159923902.1 cobalt ECF transporter T component CbiQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10526.21 Da        Isoelectric Point: 7.2793

>T144515 WP_159923892.1 NZ_CP046572:4336271-4336570 [Rhodococcus sp. WAY2]
MRPIHAAKLDKTRPVLVLTRELVRPHLSRVTVAPITGTVRGLSTEVPVGPANGLEKDSVVSCDNIVTIPVSALGHGLGFF
FPSQEAALSEAIRAAFDLE

Download         Length: 300 bp

>T144515 NZ_CP062120:c133988-133707 [Aminobacter sp. SR38]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8918.97 Da        Isoelectric Point: 4.8668

>AT144515 WP_159923890.1 NZ_CP046572:4336029-4336271 [Rhodococcus sp. WAY2]
MSTQIAVRLPDEIVAFVDGEVREHRAPSRAALVLRALERERRRQIAARDAEILSRARGEDDPDGLDDLARHAAGLFSDLD

Download         Length: 243 bp

>AT144515 NZ_CP062120:c134238-133975 [Aminobacter sp. SR38]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References