Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 938905..939452 Replicon chromosome
Accession NZ_CP046565
Organism Methylococcus sp. IM1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GNH96_RS04520 Protein ID WP_169602588.1
Coordinates 938905..939189 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GNH96_RS04525 Protein ID WP_169602589.1
Coordinates 939186..939452 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNH96_RS04505 934884..936962 - 2079 WP_169602586.1 RecQ family ATP-dependent DNA helicase -
GNH96_RS04510 937003..938164 - 1162 Protein_885 ImmA/IrrE family metallo-endopeptidase -
GNH96_RS04515 938161..938817 - 657 WP_169602587.1 N-6 DNA methylase -
GNH96_RS04520 938905..939189 - 285 WP_169602588.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GNH96_RS04525 939186..939452 - 267 WP_169602589.1 CopG family ribbon-helix-helix protein Antitoxin
GNH96_RS04530 939794..940078 - 285 WP_169602590.1 ribbon-helix-helix protein, CopG family -
GNH96_RS04535 940652..941275 + 624 WP_169602591.1 hypothetical protein -
GNH96_RS04540 941438..941941 - 504 WP_169602592.1 Hsp20/alpha crystallin family protein -
GNH96_RS04545 942015..942395 - 381 WP_169602593.1 Hsp20/alpha crystallin family protein -
GNH96_RS04550 942416..942865 - 450 WP_169602594.1 Hsp20/alpha crystallin family protein -
GNH96_RS04555 943236..943445 + 210 WP_010960118.1 cold-shock protein -
GNH96_RS04560 943612..943878 + 267 WP_169602595.1 RNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11300.91 Da        Isoelectric Point: 9.3837

>T144511 WP_169602588.1 NZ_CP046565:c939189-938905 [Methylococcus sp. IM1]
VRIEWTEPARRDLREIYLYIAQDNPYAARNLQAEIRERVTLLQDNPHLGRLGRIDGTRELVMGDNPYILPYRLRQDRIEI
LAVYHGARKWPERF

Download         Length: 285 bp

>T144511 NZ_CP062112:2099964-2100347 [Aminobacter sp. SR38]
GTGATTCTCGCGGACACGTCGATCTGGATCGATCATTTTCGCCATTCGGATGCGGAGCTGCGCCGCGTCATCGAAGAGGA
CATGCTGCTTTGCCATCCCTTCGTGATCGGCGAACTGGCGCTGGGAAGCTTGCGCGACCGAGCGACGGTGCTTGCGTTTC
TGGCGGCGCAGCGGCCAGCCGCCGTCGCCACGCATGATGAGATCATGACGATGATCGACCGGCACGGGCTGTTCAGCATG
GGCATCGGCTATACCGACGCGCACCTGCTGGCGTCGGTGCTGCTGGATCGCGGGTCGGCGCTGTGGACGCGCGACAAACG
GCTGAAAGCAGCGGCCGACAAAGCCGGCGCGGCCCTGTTCACGCCGACCGCCACCGCGAACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10246.37 Da        Isoelectric Point: 4.7156

>AT144511 WP_169602589.1 NZ_CP046565:c939452-939186 [Methylococcus sp. IM1]
MTTEAFTVRTDSETAHRLDALASRLDRSRNYLVNQAIKEYLDLHAWQIEKIQEGIEAADRGQLFPHEDVMAEMDALIQEH
IDRHEGRQ

Download         Length: 267 bp

>AT144511 NZ_CP062112:2099767-2099967 [Aminobacter sp. SR38]
ATGCGTTCCACCATCAACATCGACGACAGGCTCATGGAGAAAGCCCGCTCGCTGACCGGCACCAAGGAGACTGCCGCGAT
CGTTCGCCAGGCGCTGGAGACCCTCGTGCGTGTCGAGACGGGCAAGCGCCTGATCGCCCTCGGCGGCACGATGCCCGACG
CCAAGGCTGCGCCGCGCCGCCGTAGCGAGGCAGCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References